The novel function of adipocyte during activation of NKT cell in the obesity
Project/Area Number |
16K21347
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Metabolomics
Experimental pathology
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Research Institution | Kitasato University |
Principal Investigator |
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Research Collaborator |
Iwabuchi Kazuya
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Project Period (FY) |
2016-04-01 – 2019-03-31
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Project Status |
Completed (Fiscal Year 2018)
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Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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Keywords | NKT cell / Adipocyte / obesity / inflammation / insulin resistance / NKT細胞 / 脂肪細胞 / 脂肪組織炎症 / インスリン抵抗性 / 耐糖能異常 / 免疫学 / 細胞・組織 / 脂質 |
Outline of Final Research Achievements |
We elucidated the interaction between NKT cell and adipocyte induced adipose tissue inflammation that aggravated glucose metabolism. These evidence were proved by using adipocyte-specific Cd1d deficient mice, that inhibit interaction between NKT cell and adipocyte via CD1d. However, the lipid ligands presented by adipocyte have not been cleared. If the ligands in adipocyte will be identified in the future, NKT cell might be a new theraputic target against obesity.
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Academic Significance and Societal Importance of the Research Achievements |
肥満に伴う臓器炎症は免疫細胞によって引き起こされ、その炎症は糖尿病や肥満に深く関わっている。本研究は、肥満炎症の誘導メカニズムとしてNKT細胞が重要であることを示した。本来、感染防御に働くNKT細胞が新たに代謝疾患との関連性もあることが示唆されたことは学術的にも意義があると考えている。また、糖代謝をコントロールする上で、NKT細胞をはじめとする免疫細胞の制御も重要であることが明らかとなり、新たな治療アプロ―チとして発展していくことを期待する。
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Report
(4 results)
Research Products
(25 results)
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[Journal Article] Nerve growth factor regulation and production by macrophages in osteoarthritic synovium.2017
Author(s)
Takano S, Uchida K, Inoue G, Miyagi M, Aikawa J, Iwase D, Iwabuchi K, Matsumoto T, Satoh M, Mukai M, Minatani A, Takaso M.
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Journal Title
Clin Exp Immunol
Volume: 190
Issue: 2
Pages: 235-243
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] A Novel Mouse Model of iNKT Cell-deficiency Generated by CRISPR/Cas9 Reveals a Pathogenic Role of iNKT Cells in Metabolic Disease.2017
Author(s)
Ren Y, Sekine-Kondo E, Shibata R, Kato-Itoh M, Umino A, Yanagida A, Satoh M, Inoue K, Yamaguchi T, Mochida K, Nakae S, Van Kaer L, Iwabuchi K, Nakauchi H, Watarai H.
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Journal Title
Sci Rep
Volume: 7
Issue: 1
Pages: 12765-12765
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Invariant natural killer T cells play dual roles in the development of experimental autoimmune uveoretinitis.2016
Author(s)
Satoh M, Namba K, Kitaichi N, Endo N, Kitamei H, Iwata D, Ohno S, Ishida S, Onoe K, Watarai H, Taniguchi M, Ishibashi T,
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Journal Title
Exp Eye Res.
Volume: 153
Pages: 79-89
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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