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Amide proton transfer (APT) imaging of breast tumors

Research Project

Project/Area Number 18K07717
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 52040:Radiological sciences-related
Research InstitutionKyushu University

Principal Investigator

Kamitani Takeshi  九州大学, 大学病院, 講師 (20419534)

Co-Investigator(Kenkyū-buntansha) 鷺山 幸二  九州大学, 大学病院, 助教 (20755243)
山崎 誘三  九州大学, 大学病院, 助教 (00643347)
松浦 由布子  九州大学, 大学病院, 医員 (40825345)
日野 卓也  九州大学, 大学病院, 医員 (10807100)
筒井 聡一郎  九州大学, 大学病院, 医員 (50825346)
藪内 英剛  九州大学, 医学研究院, 教授 (70380623)
本田 浩  九州大学, 大学病院, 教授 (90145433)
Project Period (FY) 2018-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords乳癌 / MRI / CEST / APT / 乳腺
Outline of Final Research Achievements

We assessed the usefulness of APT imaging to predict the biological status of breast cancers. The triple-negative (TN) cancers showed significantly higher APT signal intensity (SI) than the luminal type cancers and HER2 cancers. APT SI had weakly positive correlation with the Ki-67 labeling index. The mean APT SIs were significantly higher for high-Ki-67 (>30%) than low-Ki-67 (≦30%) cancers. There was no significant difference in the APT SIs among nuclear grades.
These results were presented at European Congress of Radiology 2022 and a paper was published in Clinical Imaging.

Academic Significance and Societal Importance of the Research Achievements

乳癌診療においては、組織型のみならず、ホルモンレセプターやHER2発現の有無、Ki-67などの生物学的所見が治療方針に大きな影響を与える。これらの診断には組織診が不可欠であるが、病変の一部のみでの評価となる生検材料と手術標本での結果が一致しないこともあり、侵襲度が低く病変全体を評価することのできる画像で予測をつけることは臨床的に有用である。本研究では内因性Chemical Exchange Saturation Transfer(CEST)法の一種であるAmide Proton Transfer (APT) イメージングにて計測したAPT信号が生物学的所見の予測に有用であることを示した。

Report

(6 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (5 results)

All 2023 2022 2021 2020

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (1 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Amide proton transfer (APT) imaging of breast cancers and its correlation with biological status2023

    • Author(s)
      Kamitani Takeshi、Sagiyama Koji、Yamasaki Yuzo、Hino Takuya、Wada Tatsuhiro、Kubo Makoto、Akiyoshi Sayuri、Yamamoto Hidetaka、Yabuuchi Hidetake、Ishigami Kousei
    • Journal Title

      Clinical Imaging

      Volume: 96 Pages: 38-43

    • DOI

      10.1016/j.clinimag.2023.02.002

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Virtual monochromatic spectral CT imaging in preoperative evaluations for intraductal spread of breast cancer: comparison with conventional CT and MRI2023

    • Author(s)
      Matsuura Yuko、Kamitani Takeshi、Sagiyama Koji、Yamasaki Yuzo、Hino Takuya、Kubo Makoto、Ijichi Hideki、Yamamoto Hidetaka、Yabuuchi Hidetake、Ishigami Kousei
    • Journal Title

      Japanese Journal of Radiology

      Volume: - Issue: 7 Pages: 733-740

    • DOI

      10.1007/s11604-023-01392-4

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of MR imaging findings differentiating parotid basal cell adenomas from other parotid tumors2021

    • Author(s)
      Murayama Yuriko、Kamitani Takeshi、Sagiyama Koji、Yamasaki Yuzo、Hida Tomoyuki、Matsuura Yuko、Yasumatsu Ryuji、Yamamoto Hidetaka、Yabuuchi Hidetake、Ishigami Kousei
    • Journal Title

      European Journal of Radiology

      Volume: 144 Pages: 109980-109980

    • DOI

      10.1016/j.ejrad.2021.109980

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Amide proton transfer (APT) imaging of parotid tumors: Differentiation of malignant and benign tumors2020

    • Author(s)
      Kamitani Takeshi、Sagiyama Koji、Togao Osamu、Yamasaki Yuzo、Hida Tomoyuki、Matsuura Yuko、Murayama Yuriko、Yasumatsu Ryuji、Yamamoto Hidetaka、Yabuuchi Hidetake
    • Journal Title

      European Journal of Radiology

      Volume: 129 Pages: 109047-109047

    • DOI

      10.1016/j.ejrad.2020.109047

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Presentation] Amide proton transfer (APT) imaging of breast cancers: correlation with biological statuses2022

    • Author(s)
      Takeshi Kamitani, Koji Sagiyama, Yuzo Yamasaki, Tomoyuki Hida, Yuko Matsuura, Tatsuhiro Wada, Hidetake Yabuuchi, Kousei Ishigami
    • Organizer
      European Congress of Radiology (ECR) 2022
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research

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Published: 2018-04-23   Modified: 2024-01-30  

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