Higher biofunctional nano-surface modification for development of histocompatibility typed titanium implants

• Project/Area Number: 21592452
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Prosthetic dentistry
• Research Institution: Hiroshima University
• Principal Investigator: ABE Yasuhiko 広島大学, 病院, 講師 (00253097)
• Co-Investigator(Kenkyū-buntansha): HIASA Kyou 広島大学, 大学院・医歯薬学総合研究科, 助教 (60304432) ; HIRATA Isao 広島大学, 大学院・医歯薬学総合研究科, 助教 (40346507)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: チタン / インプラント / 表面改質 / Hydroxylapatite / β-tricalcium phosphate / SPR解析 / ESCA分析 / Tricalcium phosphate

Research Abstract

Concerning titanium implant coated with hydroxyapatite, processing method to treat hydroxyapatite with 30% phosphoric acid for 10 minutes was established for modification of a nanostructured surface with a ratio of calcium to phosphorus analogous toβ-tricalcium phosphate. This higher biofunctional nano-surface modification could accelerate the proliferation and differentiation of osteoblast cells

Research Products

• [Journal Article] Real timeassessment of surface interactionswith a titanium passivation layer bysurface plasmon resonance (2012)
  • Author(s): Hirata, I., Yoshida, Y., Nagaoka, N., Hiasa, K., Abe, Y., Maekawa, K., Kuboki, T., Akagawa, Y., Suzuki, K., Meerbeek, B. V., Messersmith, P. B. and Okazaki, M.
  • Journal Title: ActaBiomaterialia Volume: 8 Pages: 1260-1266
  • Peer Reviewed
• [Journal Article] Real time assessment of surface interactions with a titanium passivation layer by surface plasmon resonance (2012)
  • Author(s): Hirata, I., Yoshida, Y., Nagaoka, N., Hiasa, K., Abe, Y., Maekawa, K., Kuboki, T., Akagawa, Y., Suzuki, K., Meerbeek, B.V., Messersmith, P.B., Okazaki, M.
  • Journal Title: Acta Biomaterialia Volume: 8 Pages: 1260-1266
  • NAID: 120005308253
  • Peer Reviewed
• [Journal Article] Detection ofsynthetic RGDS(PO3H2) PA peptideadsorption using a titanium surfaceplasmon resonance(SPR) biosensor, Journal of Materials Science (2011)
  • Author(s): Abe, Y., Hiasa, K., Hirata, I. Abe, Y., Hiasa, K., Hirata, I., Okazaki, Y., Nogami, K., Mizumachi, W., Yoshida, Y., Suzuki, K., Okazaki, M. and Akagawa, Y.
  • Journal Title: Materials in Medicine Volume: 22 Pages: 657-661
  • Peer Reviewed
• [Journal Article] Detection of synthetic RGDS(PO_3H_2)PA peptide adsorption using a titanium surface plasmon resonance (SPR) biosensor (2011)
  • Author(s): Abe, Y., Hiasa, K, Hirata, I., Okazaki, Y., Nogami, K., Mizumachi, W., Yoshida, Y., Suzuki, K., Okazaki, M., Akagawa, Y.
  • Journal Title: Journal of Materials Science : Materials in Medicine Volume: 22 Pages: 657-661
  • Peer Reviewed
• [Journal Article] Degreeof immobilization of syntheticRGDS(PO3H2) PA peptides on titaniumsurfaces (2010)
  • Author(s): Abe, Y., Okazaki, Y., Hiasa, K., Hirata, I., Yoshida, Y., Taji, T., Suzuki, K. Okazaki, M. and Akagawa, Y.
  • Journal Title: Dental Materials Journal Volume: 29 Pages: 668-672
  • Peer Reviewed
• [Journal Article] Degree of immobilization of synthetic RGDS(PO_3H_2)PA peptides on titanium surfaces. (2010)
  • Author(s): Abe, Y., Okazaki, Y., Hiasa, K., Hirata, I., Yoshida, Y., Taji, T., Suzuki, K.Okazaki, M., Akagawa, Y.
  • Journal Title: Dental Materials Journal Volume: 29 Pages: 668-672
  • NAID: 10026962580
  • Peer Reviewed