| Project/Area Number |
22591450
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Gunma University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YOKOBORI Takehiko 群馬大学, 医学系研究科, 助教 (60420098)
SAKAI Makoto 群馬大学, 医学部附属病院, 助教 (70420099)
SOHDA Makoto 群馬大学, 医学部附属病院, 助教 (70507326)
KUWANO Hiroyuki 群馬大学, 医学系研究科, 教授 (90186560)
田中 成岳 群馬大学, 医学部, 助教 (30546726)
猪瀬 崇徳 群馬大学, 医学部, 助教 (90609968)
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| Project Period (FY) |
2010-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 微小転移 / 腹膜播種 / 癌 / 食道癌 / 同所移植モデル / 同所移植転移モデル微小転移 / 同所移植転移モデル |
|---|
| Outline of Final Research Achievements |
We have established mice model to evaluate peritoneal micro metastatic nest, because we could not establish orthotopic transplantation model. We used colon-26-luc cell line and 7-week-old female Balb-c mice. We could visualize micro peritoneal cancer nest as a light of luciferase. We also measured the weight of peritoneal tissue to quantify tumor volume, that related luminescence intensity. We establish the method to evaluate disease progression without sacrifice of mice.
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