The analysis of the role of SFRP2 function in immune system
| Project/Area Number |
23590368
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
YAGI Tomohito 京都府立医科大学, 医学(系)研究科(研究院), 助教 (50453098)
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| Co-Investigator(Kenkyū-buntansha) |
TANAKA Masami 京都府立医科大学, 医学部, プロジェクト研究員 (10444994)
TASHIRO Kei 京都府立医科大学, 医学研究科, 教授 (10263097)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 分子病態学 / 免疫応答 / SFRP2 / SFRP２ / カルシウムシグナル |
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| Research Abstract |
In the Wnt pathway, the secreted frizzled-related protein 2 (SFRP2, Stromal cell Derived Factor 5; SDF5) is thought to act as one of the several competitive inhibitors of Wnt. However, the precise role of SFRP2 is still poorly understood especially in B lymphocytes. Here, we studied the function of SFRP2, comparing the SFRP2 defective as well as normal B lymphocytes in mice. As a result, we revealed that calcium influx from extracellular to intracellular space in splenic B cells was clearly affected by the defect of SFRP2. In addition, the phosphorylation of phospholipase Cgammma2 was observed to be disrupted in splenic B cells. In this regard, SFRP2 is suggested to be involved in the calcium transport in the B cells as well as in the B cell receptor signaling pathway.
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Report
(4 results)
Research Products
(4 results)
