Research on inhibition of anti-cancer treatment-induced EMT and fibrosis in the background liver and hepatocellular carcinoma
Project/Area Number |
23591981
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Digestive surgery
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Research Institution | Kanazawa University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
OHTA Tetsuo 金沢大学, 医学系, 教授 (40194170)
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Project Period (FY) |
2011 – 2013
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Project Status |
Completed (Fiscal Year 2013)
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Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
Keywords | 上皮間葉転換 / 癌幹細胞 / 肝星細胞 / 癌間質 / 肝癌 / EMT / 胆道癌 / HDAC阻害剤 / paclitaxel / 原発性肝癌 / 胆管細胞癌 / Paclitaxel / パクリタキセル / 線維化 |
Research Abstract |
Epithelial-mesenchymal transition (EMT) in tissue fibrosis and cancer metastasis and invasion has been noted, but the EMT is induced in cancer cells by anti-cancer therapy itself has become a hot topic in recent years. It is well known that tissue fibrosis and EMT are inhibited by low dose administered taxan and histone deacetylase (HDAC) inhibitor. It has been shown that paclitaxel suppresses the induction of EMT in primary liver cancer (intrahepatic cholangiocarcinoma) cell line in the current study, HDAC inhibitors (sodium valproate) and paclitaxel inhibited activation of hepatic stellate cells.
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Report
(4 results)
Research Products
(16 results)
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[Journal Article] Low-dose paclitaxel inhibits the induction of epidermal-mesenchymal transition in the human cholangiocarcinoma CCKS-1 cell line.2013
Author(s)
ATSUSHI HIROSE, HIDEHIRO TAJIMA, TETSUO OHTA, TOMOYA TSUKADA, KOICHI OKAMOTO, SHINICHI NAKANUMA, SEISHO SAKAI, JUN KINOSHITA, ISAMU MAKINO, HIROYUKI FURUKAWA, HIRONORI HAYASHI, KEISHI NAKAMURA, KATSUNOBU OYAMA, MASAFUMI INOKUCHI, HISATOSHI NAKAGAWARA, TOMOHARU MIYASHITA, HIROYUKI TAKAMURA, ITASU NINOMIYA, et al.
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Journal Title
ONCOLOGY LETTERS
Volume: 6
Issue: 4
Pages: 915-920
DOI
Related Report
Peer Reviewed
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