• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Development of a new type of anti-tuberculosis vaccines by the use of lipid immunity

Research Project

Project/Area Number 24390255
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Infectious disease medicine
Research InstitutionKyoto University

Principal Investigator

SUGITA Masahiko  京都大学, ウイルス研究所, 教授 (80333532)

Co-Investigator(Kenkyū-buntansha) IGARASHI Tatuhiko  京都大学, ウイルス研究所, 教授 (90467431)
NAKAMURA Takashi  北海道大学, 薬学研究科(研究院), 助教 (20604458)
HARASHIMA Hideyoshi  北海道大学, 薬学研究科(研究院), 教授 (00183567)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2014: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2012: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
Keywords結核 / ワクチン / 脂質
Outline of Final Research Achievements

As about one third of the world population is infected with Mycobacterium tuberculosis, the infectious agent that causes human tuberculosis, the development of more effective vaccines than BCG, the only anti-tuberculosis vaccine currently available worldwide, is urgently needed. This principal investigator has contributed to advances in the frontier research of immune responses against tuberculosis-associated lipids. In this project, this research group has attempted to extend the basic achievements to the development of a new type of lipid-based vaccines against human tuberculosis. Using the guinea pig model of human tuberculosis, this group was successful in establishing a prototypic lipid vaccine. Furthermore, a new protocol capable of efficiently eliciting lipid-specific immune responses has been established for non-human primates, such as rhesus monkeys. These contributions provide the basis for the future development of anti-tuberculosis vaccines against human tuberculosis.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (7 results)

All 2015 2014 2013 2012 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Acknowledgement Compliant: 1 results) Presentation (1 results) (of which Invited: 1 results) Remarks (3 results)

  • [Journal Article] Glycerol monomycolate is a novel ligand for the human, but not mouse macrophage inducible C-type lectin, Mincle.2014

    • Author(s)
      Hattori Y, Morita, D, Fujiwara N, Mori D, Nakamura T, Harashima H, Yamasaki S, Sugita M.
    • Journal Title

      The Journal of Biological Chemistry

      Volume: 289(22) Issue: 22 Pages: 15405-12

    • DOI

      10.1074/jbc.m114.566489

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Th1-skewed tissue responses to a mycolyl glycolipid in mycobacteria-infected rhesus macaques.2013

    • Author(s)
      Morita D, Miyamoto A, Hattori Y, Komori T, Nakamura T, lgarashi T, Harashima H, Sugita M
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 441(1) Issue: 1 Pages: 108-113

    • DOI

      10.1016/j.bbrc.2013.10.021

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Major T cell response to a mycolyl glycolipid is mediated by CD1c mole cules in rhesus macaques.2012

    • Author(s)
      森田大輔、服部祐季、杉田昌彦
    • Journal Title

      Infection and Imuunity

      Volume: 81巻No.1 Issue: 1 Pages: 311-366

    • DOI

      10.1128/iai.00871-12

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] 脂質免疫:結核菌やエイズウイルスに対抗する新しい獲得免疫システム2015

    • Author(s)
      杉田昌彦
    • Organizer
      第89回日本感染症学会総会
    • Place of Presentation
      京都
    • Year and Date
      2015-04-16 – 2015-04-17
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Remarks] 京大ウイルス研・杉田研究室

    • URL

      http://www.virus.kyoto-u.ac.jp/Lab/SugitaLab.html

    • Related Report
      2014 Annual Research Report
  • [Remarks] 京大ウイルス研・杉田研究室

    • URL

      http://www.virus.kyoto-u.ac.jp/Lab/SugitaLab.html

    • Related Report
      2013 Annual Research Report
  • [Remarks]

    • URL

      http://www.virus.kyoto-u.ac.jp/Lab/SugitaLab.html

    • Related Report
      2012 Annual Research Report

URL: 

Published: 2012-04-24   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi