Development of a new type of anti-tuberculosis vaccines by the use of lipid immunity
| Project/Area Number |
24390255
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Infectious disease medicine
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
IGARASHI Tatuhiko 京都大学, ウイルス研究所, 教授 (90467431)
NAKAMURA Takashi 北海道大学, 薬学研究科(研究院), 助教 (20604458)
HARASHIMA Hideyoshi 北海道大学, 薬学研究科(研究院), 教授 (00183567)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2014: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2012: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
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| Keywords | 結核 / ワクチン / 脂質 |
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| Outline of Final Research Achievements |
As about one third of the world population is infected with Mycobacterium tuberculosis, the infectious agent that causes human tuberculosis, the development of more effective vaccines than BCG, the only anti-tuberculosis vaccine currently available worldwide, is urgently needed. This principal investigator has contributed to advances in the frontier research of immune responses against tuberculosis-associated lipids. In this project, this research group has attempted to extend the basic achievements to the development of a new type of lipid-based vaccines against human tuberculosis. Using the guinea pig model of human tuberculosis, this group was successful in establishing a prototypic lipid vaccine. Furthermore, a new protocol capable of efficiently eliciting lipid-specific immune responses has been established for non-human primates, such as rhesus monkeys. These contributions provide the basis for the future development of anti-tuberculosis vaccines against human tuberculosis.
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Report
(4 results)
Research Products
(7 results)
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[Journal Article] Glycerol monomycolate is a novel ligand for the human, but not mouse macrophage inducible C-type lectin, mincle2014
Author(s)
Hattori Y, Morita, D, Fujiwara N, Mori D, Nakamura T, Harashima H, Yamasaki S, Sugita M.
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Journal Title
J Biol Chem.
Volume: 289(22)
Pages: 15405-12
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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