| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2014: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2012: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
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| Outline of Final Research Achievements |
This study is aimed to investigate the relationship between tropical area-specific endemic neurodegenerative diseases and their dietary habits. We performed a field survey about the distribution of Annona Muricata, the occurrence of the disease, and their dietary habits, especially in Guam. We clarified that O,O-dimethylcoclaurine (DMC) involved in the Annona Muricata inhibits P-glycoprotein (P-gp) and is also a substrate of P-gp. DMC exerted weak neurotoxicty in in vivo. Taken together, it is suggested that DMC might be one of the candidate substances related to the disease.
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