Preparation of novel iontophoresis electrodes by an electrolytic deposition method

• Project/Area Number: 24760570
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Structural/Functional materials
• Research Institution: Tokyo Institute of Technology
• Principal Investigator: YOSHIOKA Tomohiko 東京工業大学, 理工学研究科, 助教 (50452016)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: イオントフォレシス / 経皮吸収 / DDS

Research Abstract

This study is concerned with the preparation of novel iontophoresis electrodes delivering drugs through the skin into the body. The electrodes were prepared by electrochemical deposition of alginic acid gels on aluminum substrates. The deposited gels were tightly bonded on the substrates through the interaction between alginic acid and surface oxides of the substrates. The electrodes prepared loaded lidocaine electrostatically, and released the drug by applying external electric fields. Equivalent circuits for the electrode/rat skin system were analyzed, so that the use of AC iontophoresis is thought to be effective for transdermal drug delivery with the electrode prepared.

Research Products

• [Presentation] アルギン酸電極を用いたリドカインの交流イオントフォレーシス (2014)
  • Author(s): 吉岡朋彦、生駒俊之、海老澤智子、松本勝洋、中島淳、灰田悠、安藤寧、脇田亮、深山治久、田中順三
  • Organizer: 日本セラミックス協会2014年年会
  • Place of Presentation: 慶応義塾大学(神奈川)
  • Year and Date: 2014-03-17
• [Presentation] アルギン酸電極を用いたリドカインの交流イオントフォレーシス (2014)
  • Author(s): 吉岡朋彦、生駒俊之、海老澤智子、松本勝洋、中島淳、灰田悠、安藤寧、脇田亮、深山治久、田中順三
  • Organizer: 日本セラミックス協会2014年年会
  • Place of Presentation: 慶応義塾大学、横浜市
• [Presentation] AC Iontophoresis of Lidocaine with Alginic-Acid Gel Electrodes (2013)
  • Author(s): Tomoko Ebisawa, Katsuhiro Matsumoto, Atsuhi Nakajima, Haruka Haida, Shizuka Ando, Tomohiko Yoshioka, Toshiyuki Ikoma, Junzo Tanaka, and Haruhisa Fukayama
  • Organizer: The 4^<th> International Symposium on Advanced Materials Development and Integration of Novel Structured Metallic and Inorganic Materials (AMDI-4)
  • Place of Presentation: Nagoya University (Nagoya, Japan)
  • Year and Date: 2013-12-14
• [Presentation] Calcium Alginate Gels as Electrode Material for Iontophoresis of Lidocaine (2013)
  • Author(s): Tomoko Ebisawa, Katsuhiro Matsumoto, Astsushi Nakajima, Haruka Haida, Shizuka Ando, Tomohiko Yoshioka, Toshiyuki Ikoma, Junzo Tanaka, Haruhisa Fukayama
  • Organizer: The 7^<th> International Conference on the Science and Technology for Advanced Ceramics (STAC-7)
  • Place of Presentation: Mielparque Yokohama (Kanagawa, Japan)
  • Year and Date: 2013-06-20
• [Presentation] Calcium Alginate Gels as Electrode Material for Iontophoresis of Lidocaine (2013)
  • Author(s): Tomoko Ebisawa, Katsuhiro Matsumoto, Astsushi Nakajima, Haruka Haida, Shizuka Ando, Tomohiko Yoshioka, Toshiyuki Ikoma, Junzo Tanaka, Haruhisa Fukayama
  • Organizer: The 7th International Conference on the Science and Technology for Advanced Ceramics (STAC-7)
  • Place of Presentation: メルパルク横浜、横浜市
• [Presentation] AC Iontophoresis of Lidocaine with Alginic-Acid Gel Electrodes (2013)
  • Author(s): Tomoko Ebisawa, Katsuhiro Matsumoto, Atsuhi Nakajima, Haruka Haida, Shizuka Ando, Tomohiko Yoshioka, Toshiyuki Ikoma, Junzo Tanaka, and Haruhisa Fukayama
  • Organizer: The 4th International Symposium on Advanced Materials Development and Integration of Novel Structured Metallic and Inorganic Materials (AMDI-4)
  • Place of Presentation: 名古屋大学
• [Presentation] Electro-responsive drug delivery of electrochemically deposited alginic acid gels on metals (2012)
  • Author(s): Tomohiko Yoshioka, Norio Saito, Toshiyuki Ikoma, Naoki Ohashi, Tomoko Ebisawa, Haruka Haida, Atsuhi Nakajima, Ryo Wakita, Haruhisa Fukayama, Masahiro Umino, and Junzo Tanaka
  • Organizer: The 3^<rd> International Symposium on Advanced Materials Development and Integration of Novel Structured Metallic and Inorganic Materials (AMDI-3)
  • Place of Presentation: Hotel Nikko Toyohashi (Aichi, Japan)
  • Year and Date: 2012-11-05
• [Presentation] Electrochemically deposited gels for transdermal drug delivery (2012)
  • Author(s): Tomohiko Yoshioka, Norio Saito, Toshiyuki Ikoma, Naoki Ohashi, Haruka Haida, Atsushi Nakajima, Ryo Wakita, Haruhisa Fukayama, Masahiro Umino, and Junzo Tanaka
  • Organizer: 9^<th> World Biomaterials Congress
  • Place of Presentation: Century City International Convention Center (Chengdu, China)
• [Presentation] Electrochemically deposited gels for transdermal drug delivery (2012)
  • Author(s): Tomohiko Yoshioka, Norio Saito, Toshiyuki Ikoma, Naoki Ohashi, Haruka Haida, Atsushi Nakajima, Ryo Wakita, Haruhisa Fukayama, Masahiro Umino, and Junzo Tanaka
  • Organizer: 9th World Biomaterials Congress
  • Place of Presentation: Chengdu, China
• [Presentation] Electro-responsive drug delivery of electrochemically deposited alginic acid gels on metals (2012)
  • Author(s): Tomohiko Yoshioka, Norio Saito, Toshiyuki Ikoma, Naoki Ohashi, Tomoko Ebisawa, Haruka Haida, Atsuhi Nakajima, Ryo Wakita, Haruhisa Fukayama, Masahiro Umino, and Junzo Tanaka
  • Organizer: The 3rd International Symposium on Advanced Materials Development and Integration of Novel Structured Metallic and Inorganic Materials
  • Place of Presentation: Toyohashi, Japan
• [Remarks]
  • URL: http://www.bio.ceram.titech.ac.jp/