The role of B celIs in a murine model of human psoriasis
Project/Area Number |
24791137
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Dermatology
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Research Institution | The University of Tokyo |
Principal Investigator |
YANABA Kouichi 東京大学, 医学部附属病院, 助教 (80385369)
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Project Period (FY) |
2011 – 2013
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | 乾癬 / B細胞 / マウス / CD19 / B細胞 |
Research Abstract |
Psoriasis is an inflammatory cutaneous disorder characterized by marked epidermal thickening with T helper l and 17 cell infiltration. At present, the contribution of B cells to the pathogenesis of psoriasis is unclear. In mice, topical apPlication of imiquimod induces inflamed skin lesions resembling human psoriasis and serves as an experimental animal model for human psoriasis. In this study, we have shown that imiquimod-induced skin inflammation was more severe in CD19-deficient mice than in wild-type mice. These inflammatory responses were negatively regulated by a unique interleukin-10-producing CDld^<hi>CD5^+regulatory B cell subset (B10 cells) that was absent in CD19-deficient mice and represented only 1-2% of splenic B220^+ cells in wild-type mice. Splenic B10 cells entered the circulation and migrated to draining lymph nodes during imiquimod-induced skin inflammation, thereby suppressing interferon-・ and interleukin-17 production. Furthermore, adoptive transfer of these BIO cells from wild-type mice reduced inflammation in CD19-deficient mice. The present findings provide direct evidence that B10 cells regulate imiquimod-induced skin inflammation and offer insights into regulatory B cell- based therapies for the treatment of psoriasis.
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Report
(3 results)
Research Products
(4 results)
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[Journal Article] Regulatory B cells suppress imiquimod-induced, psoriasis-like skin inflammation2013
Author(s)
Yanaba K, Kamata M, Ishiura N, Shibata S, Asano Y, Tada Y, Sugaya M, Kadono T, Tedder TF, Sato S
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Journal Title
J Leukoc Biol
Volume: 94
Issue: 4
Pages: 563-573
DOI
Related Report
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