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Analyses of glucagon related peptides in amacrine cells of eyes induced form deprivation myopia

Research Project

Project/Area Number 25861622
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Ophthalmology
Research InstitutionTokyo Medical and Dental University

Principal Investigator

Nagaoka Natsuko  東京医科歯科大学, 医学部附属病院, 医員 (30626271)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords実験近視 / アマクリン細胞 / グルカゴン / ラット / GIP / VIP / 視覚刺激遮断 / グルカゴンファミリー / 実験近視モデル / 近視 / マウスモデル
Outline of Final Research Achievements

We analyzed the change of the expression of glucagon family in Amacrine cells of the retina in the progression of myopia using rat experimental myopia model. Immunohistochemical examinations showed GIP and VIP which were members of glucagon family in Amacrine cells in the retina both in the normal control and the myopia induced eyes. We analyzed the expression level of the mRNA of GIP and VIP by RT-PCR, and GIP and VIP protein expression amount by Western blotting, and they showed decreased expression of mRNA of GIP and VIP, GIP and VIP protein in myopia induced eyes compared with the normal control eyes. These substances were suggested to be associated with myopia progression. These results are expected to be useful for developing a therapy to inhibit the progression of myopia.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (1 results)

All 2015

All Presentation (1 results)

  • [Presentation] ラットを用いた新しい実験近視動物モデルの開発2015

    • Author(s)
      長岡 奈都子
    • Organizer
      第119回日本眼科学会総会
    • Place of Presentation
      ロイトン札幌(北海道、札幌)
    • Year and Date
      2015-04-16
    • Related Report
      2015 Annual Research Report

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Published: 2014-07-25   Modified: 2019-07-29  

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