Neuronal remodeling after focal stroke induced by astrocyte stimulation
| Project/Area Number |
26460315
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Environmental physiology(including physical medicine and nutritional physiology)
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| Research Institution | Gunma University |
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Principal Investigator |
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| Research Collaborator |
AMANO Izuki
OBI Kisho
TOBITA Seiji
YOSHIHARA Toshitada
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 脳梗塞 / アストロサイト / ドパミン / アリピプラゾール / 神経回路再編成 / グルタミン酸 / 2光子励起レーザー顕微鏡 / 機能局在 / DHEA |
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| Outline of Final Research Achievements |
In this study, we observed the role of astrocyte on remodeling for functional compensation in contralateral hemisphere of focal stroke. We found that dopamine is one of the strong candidate for contributing the functional remodeling/recovery after focal stroke. We also found that repetitive application of Aripiprazole, one of the partial agonist for dopamine receptor, enhances the remodeling of neuronal circuit in intact hemisphere after focal stroke. Since the Aripiprazole enhances the activity of astrocyte if it repetitively applied, our study suggested that application of aripiprazole enhances the neuronal remodeling after focal stroke via activation of dopaminergic systems.
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Report
(4 results)
Research Products
(21 results)
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[Journal Article] Possible involvement of IGF-1 signaling on compensatory growth of the infraspinatus muscle induced by the supraspinatus tendon detachment of rat shoulder2014
Author(s)
Ichinose T, Lesmana R, Yamamoto A, Kobayashi T, Shitara H, Shimoyama D, Takatsuru Y, Iwasaki T, Shimokawa N, Takagishi K, Koibuchi N
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Journal Title
Physiological Rep
Volume: 2
Issue: 1
Pages: 1-10
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Altered cerebellum development and dopamine distribution in a rat genetic model with congenital hypothyroidism.2014
Author(s)
Shimokawa N, Yousefi B, Morioka S, Yamaguchi S, Ohsawa A, Hayashi H, Azuma A, Mizuno H, Kasagi M, Masuda H, Jingu H, Furudate SI, Haijima A, Takatsuru Y, Iwasaki T, Umezu M, Koibuchi N.
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Journal Title
J Neuroendocrinol.
Volume: 26
Issue: 3
Pages: 164-175
DOI
Related Report
Peer Reviewed / Open Access
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