Project/Area Number |
26860868
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Dermatology
|
Research Institution | Jikei University School of Medicine |
Principal Investigator |
YANABA KOICHI 東京慈恵会医科大学, 医学部, 講師 (80385369)
|
Project Period (FY) |
2014-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | 免疫複合体病 / B細胞 / アルサス反応 / 免疫複合体 / CD19 |
Outline of Final Research Achievements |
(Background) To examine whether IL-10-producing regulatory B cells play a role in immune complex-induced tissue injury using reverse passive Arthus reaction.(Methods) Cutaneous and peritoneal reverse passive Arthus reaction was examined in mice lacking CD19, which have few regulatory B cells.(Results) CD19 deficiency had no effect on cutaneous reverse passive Arthus reaction. By contrast, enhanced neutrophil infiltration was observed in CD19-/- mice, whereas mast cell infiltration was comparable between wild-type and CD19-/- mice. Furthermore, the increased peritoneal inflammatory responses by CD19 loss were associated with the increased IL-6 release, whereas inversely correlated with the reduced IL-10 secretion.(Conclusion) IL-10-producing regulatory B cells might play an inhibitory role in immune complex-induced tissue injury.
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