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New indications and possibility for other brain malignancies for BNCT using positron emission tomography

Research Project

Project/Area Number 21890283
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Cerebral neurosurgery
Research InstitutionOsaka Medical College

Principal Investigator

MIYATA Shirou  Osaka Medical College, 医学部, 非常勤医師 (30550230)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2010: ¥1,235,000 (Direct Cost: ¥950,000、Indirect Cost: ¥285,000)
Fiscal Year 2009: ¥1,365,000 (Direct Cost: ¥1,050,000、Indirect Cost: ¥315,000)
Keywords脳腫瘍 / PET / アミノ酸 / LAT-1 / 中性子捕捉療法 / BPA / 転移性脳腫瘍 / 画像診断
Research Abstract

In our basic experiment, accumulation of F-BPA and BPA had some differences. By the case which accumulation of F-BPAPET was high in, the LAT-1 staining showed strong positive depending on accumulation by the PET. Only blood vessel was strong positive by some cases, and it was thought that the adaptation to BNCT should be careful. Also, we think about BPA-PET with an essential examination when accumulation of F-BPAPET remains for many metastatic brain tumors moderately and decides by indication of BNCT using BPA for a metastatic brain tumor.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (23 results)

All 2011 2010 2009 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (19 results)

  • [Journal Article] CT imaging of transferrin targeting liposomes encapsulating both boron and iodine contrast agent by CED to F98 rat glioma for boron neutron capture therapy.2011

    • Author(s)
      Miyata S, Kawabata S, Hiramatsu R, Doi A, Ikeda N, Yamashita T, Kuroiwa T, Kasaoka S, Maruyama K, Miyatake SI
    • Journal Title

      Neurosurgery. 68

      Pages: 1380-1387

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 18F-BPA-PETを用いた悪性脳腫瘍治療後の病態解析2009

    • Author(s)
      川端信司,宮武伸一,宮下実,宮田至朗,平松亮,嶽北葉子,山田佳孝,池田直廉,黒岩敏彦,今堀良夫
    • Journal Title

      CI研究 31

      Pages: 145-151

    • NAID

      10026325247

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] ^<18>F-BPA-PETを用いた悪性脳腫瘍治療後の病態解析2009

    • Author(s)
      川端信司, 宮田至朗, ほか
    • Journal Title

      CI研究 31

      Pages: 145-151

    • NAID

      10026325247

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CT imaging of transferrin targeting liposomes encapsulating both boron and iodine contrast agent by CED to F98 rat glioma for boron neutron capture therapy.

    • Author(s)
      Miyata S, Kawabata S, ほか
    • Journal Title

      Neurosurgery.

      Volume: (印刷中)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Amino acid PET (18F-laveled borono-phenylalanine positron emission tomography) around our modified boron neutroncapture therapy.2011

    • Author(s)
      S.Kawabata, S.Miyata, ほか
    • Organizer
      The 4^<th> international neurosurgical winter congress
    • Place of Presentation
      北海道、ルスツ
    • Related Report
      2010 Final Research Report
  • [Presentation] Amino acid PET (^<18>F-laveled borono-phenylalanine positron emission to mography) around our modified boron neutron capture therapy2011

    • Author(s)
      S.Kawabata, S.Miyata, ほか
    • Organizer
      The 4^<th> international neurosurgical winter congress
    • Place of Presentation
      北海道、ルスツ
    • Related Report
      2010 Annual Research Report
  • [Presentation] 悪性神経膠腫に対するホウ素中性子捕捉療法に関する最近の取り組み2010

    • Author(s)
      川端信司、宮田至朗, ほか
    • Organizer
      第28回日本脳腫瘍学会学術集会
    • Place of Presentation
      軽井沢
    • Year and Date
      2010-11-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] 膠芽腫に対するホウ素中性子捕捉療法、X線外照射、化学療法~第II相臨床試験の近況2010

    • Author(s)
      川端信司、宮田至朗, ほか
    • Organizer
      第48回日本癌治療学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2010-10-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] 悪性神経膠腫に対するホウ素中性子捕捉療法~多施設共同試験の概要と進捗状況~2010

    • Author(s)
      川端信司、宮田至朗, ほか
    • Organizer
      社団法人日本脳神経外科学会第69回学術総会
    • Place of Presentation
      福岡
    • Year and Date
      2010-10-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] Combination of BNCT and XRT for glioblastoma-single institutional experience and future prospects-2010

    • Author(s)
      S.Kawabata, S.Miyata, ほか
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪
    • Year and Date
      2010-09-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] Recent progress of boron neutron capture therapy (BNCT) for malignant glioma.2010

    • Author(s)
      S.Kawabata, S.Miyata, ほか
    • Organizer
      The 9^<th> International Conference of the Asian Clinical Oncology Society
    • Place of Presentation
      岐阜
    • Year and Date
      2010-08-26
    • Related Report
      2010 Final Research Report
  • [Presentation] Recent progress of boron neutron capture therapy (BNCT) for malignant glioma2010

    • Author(s)
      S.Kawabata, S.Miyata, ほか
    • Organizer
      The 9^<th> International Conference of the Asian Clinical Oncology Society
    • Place of Presentation
      岐阜
    • Year and Date
      2010-08-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] 加速器BNCTへ向けた原子炉BNCTによる多施設共同第2相臨床試験2010

    • Author(s)
      川端信司、宮田至朗, ほか
    • Organizer
      第7回日本中性子捕捉療法学会学術大会
    • Place of Presentation
      東京
    • Year and Date
      2010-08-06
    • Related Report
      2010 Final Research Report
  • [Presentation] 加速器BNCTへ向けた原子炉BNCTによる多施設共同第2相臨床試験2010

    • Author(s)
      川端信司、宮田至朗, ほか
    • Organizer
      第7回日本中性子補捉療法学会学術大会
    • Place of Presentation
      東京
    • Year and Date
      2010-08-06
    • Related Report
      2010 Annual Research Report
  • [Presentation] Modified Boron Neutron Capture Therapy for Malignant Glioma-Our Modified Protocol and Future Directions-2010

    • Author(s)
      S.Kawabata, S.Miyata, ほか
    • Organizer
      The 7^<th> Asian Society for Neuro-Oncology
    • Place of Presentation
      ソウル、韓国
    • Year and Date
      2010-06-11
    • Related Report
      2010 Annual Research Report
  • [Presentation] Boron neutron capture therapy for malignant meningiomas.2010

    • Author(s)
      S.Kawabata, S.Miyata, ほか
    • Organizer
      The 7^<th> Asian Society for Neuro-Oncology
    • Place of Presentation
      ソウル、韓国
    • Related Report
      2010 Final Research Report
  • [Presentation] ^<18>F-labeled BPA Positron Emission Tomography based Boron Neutron Capture Therapy -our New indications and possibility for any other brain malignancies.2010

    • Author(s)
      S.Kawabata, S.Miyata, ほか
    • Organizer
      The 7^<th> Asian Society for Neuro-Oncology
    • Place of Presentation
      ソウル、韓国
    • Related Report
      2010 Final Research Report
  • [Presentation] Boron neutron capture therapy for malignant meningiomas2010

    • Author(s)
      S.Kawabata, S.Miyata, ほか
    • Organizer
      The 7^<th> Asian Society for Neuro-Oncology
    • Place of Presentation
      ソウル、韓国
    • Related Report
      2010 Annual Research Report
  • [Presentation] ^<18>F-labeled BPA Positron Emission Tomography based Boron Neutron Capture Therapy -our New indications and possibility for any other brain malignancies2010

    • Author(s)
      S.Kawabata, S.Miyata, ほか
    • Organizer
      The 7^<th> Asian Society for Neuro-Oncology
    • Place of Presentation
      ソウル、韓国
    • Related Report
      2010 Annual Research Report
  • [Presentation] 脳腫瘍に対する硼素中性子捕捉療法~加速器中性子源を目前にして~2009

    • Author(s)
      川端信司, 宮田至朗, ほか
    • Organizer
      第27回 日本脳腫瘍学会
    • Place of Presentation
      りんくう国際会議場(大阪)
    • Year and Date
      2009-11-08
    • Related Report
      2009 Annual Research Report
  • [Presentation] 悪性髄膜腫に対する硼素中性子捕捉療法~自検例のその後と今後の展望2009

    • Author(s)
      川端信司、宮田至朗, ほか
    • Organizer
      第6回日 本中性子捕捉療法学会
    • Place of Presentation
      キャンパスプラザ京都(京都)
    • Year and Date
      2009-09-20
    • Related Report
      2010 Final Research Report
  • [Presentation] 悪性髄膜腫に対する硼素中性子捕捉療法~自検例のその後と今後の展望2009

    • Author(s)
      川端信司, 宮田至朗, ほか
    • Organizer
      第6回 日本中性子捕捉療法学会
    • Place of Presentation
      キャンパスプラザ京都(京都)
    • Year and Date
      2009-09-20
    • Related Report
      2009 Annual Research Report
  • [Presentation] 悪性髄膜腫モデルを用いた硼素中性子捕捉療法の治療効果2009

    • Author(s)
      大西恭子, 宮田至朗, ほか
    • Organizer
      第6回 日本中性子捕捉療法学会
    • Place of Presentation
      キャンパスプラザ京都(京都)
    • Year and Date
      2009-09-19
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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