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Re-direction of the differentiation status by a novel protein transduction system LENA

Research Project

Project/Area Number 24310146
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Medical genome science
Research InstitutionNational Hospital Organization Nagoya Medical Center (2014)
Osaka Prefectural Institute of Public Health (2012-2013)

Principal Investigator

KOMANO Atsushi  独立行政法人国立病院機構(名古屋医療センター臨床研究センター), その他部局等, その他 (60356251)

Co-Investigator(Kenkyū-buntansha) TAKEDA Satoshi  国立感染症研究所, エイズ研究センター, 研究員 (50396959)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥20,280,000 (Direct Cost: ¥15,600,000、Indirect Cost: ¥4,680,000)
Fiscal Year 2014: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2013: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2012: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
Keywords移植•再生医療 / バイオテクノロジー / レンチウイルス様ナノ粒子 / 脱分化法 / ナノバイオ / 再生医療 / 移植・再生医療
Outline of Final Research Achievements

For the establishment of safe re-direction protocol, we evaluated the protein delivery system LENA. We have shown that a transcription factor. Oct3/4 is successfully delivered to human cells via LENA. However, we found that the system have a room to improve because the biological function of Oct3/4 is detected weakly. We designed the second generation LENA to achieve the goal of this study.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (34 results)

All 2015 2014 2013 2012

All Journal Article (13 results) (of which Peer Reviewed: 13 results,  Open Access: 2 results) Presentation (20 results) Patent(Industrial Property Rights) (1 results) (of which Overseas: 1 results)

  • [Journal Article] Impact of genotype-specific herd immunity on the circulatory dynamism of norovirus: a 10-year longitudinal study of viral acute gastroenteritis.2014

    • Author(s)
      Sakon N, Yamazaki K, Nakata K, Kanbayashi D, Yoda T, Mantani M, Kase T, Takahashi K, *Komano J.
    • Journal Title

      J Infect Dis

      Volume: 211 Issue: 6 Pages: 879-888

    • DOI

      10.1093/infdis/jiu496

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Reply: Pitfalls of National Surveillance Systems for Vaccine-associated Measles.2014

    • Author(s)
      Kurata T, Kanbayashi D, Komano J*, Kase T, Takahashi K.
    • Journal Title

      Am J Med

      Volume: 127 Issue: 8 Pages: 19-19

    • DOI

      10.1016/j.amjmed.2014.04.027

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Novel role of HSP40/DNAJ in the regulation of HIV-1 replication2013

    • Author(s)
      Urano E, Morikawa Y, Komano J
    • Journal Title

      JAIDS

      Volume: (In press)

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel therapeutic molecule against HTLV-1 infection targeting provirus.2013

    • Author(s)
      Tanaka A, Takeda S, Kariya R, Matsuda K, Urano E, Okada S, Komano J
    • Journal Title

      Leukemia

      Volume: (In press) Issue: 8 Pages: 1621-1627

    • DOI

      10.1038/leu.2013.46

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prevalence and epidemiological traits of HIV infections in populations with high risk behaviors as revealed by genetic analysis of HBV.2013

    • Author(s)
      Kojima Y, Kawahata T, Mori H, Furubayashi K, Taniguchi Y, Iwasa A, Taniguchi K, Kimura H, Komano J
    • Journal Title

      Epidemiology and Infection.

      Pages: 1-8

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Elicitation of both anti HIV-1 env humoral and cellular immunities by replication vaccinia prime sendai virus boost regimen and boosting by CD40Lm2012

    • Author(s)
      Zhang X
    • Journal Title

      PLoS ONE

      Volume: 7 Issue: 12 Pages: 1-11

    • DOI

      10.1371/journal.pone.0051633

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Toll-like receptor (TLR) 3 as a potential sensor of retroviral infection in human cells.2012

    • Author(s)
      Miyauchi K, Urano E, Takeda S, Murakami T, Okada Y, Cheng K, Yin H, Kubo M, Komano J
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 12 Issue: 3 Pages: 109-116

    • DOI

      10.1016/j.bbrc.2012.06.148

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of Cyclin T1 expression and function by an alternative splice variant that skips exon 7 and contains a premature termination codon.2012

    • Author(s)
      Urano E, Miyauchi K, Ichikawa R, Futahashi Y, Komano J
    • Journal Title

      Gene.

      Volume: 505 Issue: 1 Pages: 1-8

    • DOI

      10.1016/j.gene.2012.06.006

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neutrophil extracellular traps mediate a host defense response to human immunod eficiency virus-12012

    • Author(s)
      Saitoh T, Komano J, Saitoh Y, Misawa T, Takahama M, Kozaki T, Uehata T, Iwasaki H, Omori H, Yamaoka S, Yamamoto N, Akira S.
    • Journal Title

      Cell Host Microbe.

      Volume: 12 Pages: 109-116

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neutrophil extracellular traps mediate a host defense response to human immunodeficiency virus-1.2012

    • Author(s)
      Saitoh T, Komano J, Saitoh Y, Misawa T, Takahama M, Kozaki T, Uehata T, Iawasaki H. Omori H, Yamaoka S, Yamamoto N, Akira S.
    • Journal Title

      Cell Host Microbe.

      Volume: 12(1) Issue: 1 Pages: 109-116

    • DOI

      10.1016/j.chom.2012.05.015

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of a Synthetic C34 Trimer of HIV-1 gp41 as AIDS Vaccines2012

    • Author(s)
      Hashimoto, C., Nomura, W., Ohya, A., Urano, E., Miyauchi, K., Narumi, T., Aikawa, H., Komano, J.A., Yamamoto, N., Tamamura, H.
    • Journal Title

      Bioorg.Med.Chem.

      Volume: (in press) Issue: 10 Pages: 3287-3291

    • DOI

      10.1016/j.bmc.2012.03.050

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Therapeutic potential of HIV protase-activable CASP3.2012

    • Author(s)
      Miyauchi K, Urano E, Takizawa M, Ichikawa R, Komano J
    • Journal Title

      Scientific Reports.

      Volume: 2 Issue: 1 Pages: 359-359

    • DOI

      10.1038/srep00359

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Synthetic C34 Trimer of HIV-1 gp41 Shows Significant Increase of In hibition Potency.2012

    • Author(s)
      Nomura W, Hashimoto C, Ohya A, Miyauchi K, Urano E, Tanaka T, Narumi T, Nakahara T, Komano J, Yamamoto N, Tamamura H
    • Journal Title

      ChemMedChem.

      Volume: 7 Pages: 546-546

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] 先天性風疹症候群の追跡調査の現状と出生時診断の留意点について.2015

    • Author(s)
      上林大起, 倉田貴子, 福村和美, 畑中己穂, 田邊雅章, 松本治子, 駒野 淳, 加瀬哲男, 高橋和郎, 五十嵐愛, 北島博之
    • Organizer
      第26回日本臨床微生物学会総会・学術集会
    • Place of Presentation
      東京
    • Year and Date
      2015-01-31 – 2015-02-01
    • Related Report
      2014 Annual Research Report
  • [Presentation] 急速な病期進行をみた感染初期例群に共通して検出された新規変異HIV-1の流行実態.2014

    • Author(s)
      森 治代, 小島洋子, 川畑拓也, 駒野 淳.
    • Organizer
      第28回日本エイズ学会学術集会・総会
    • Place of Presentation
      大阪
    • Year and Date
      2014-12-03 – 2014-12-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] βグルコセレブロシダーゼが持つエンテロウイルス 71 感染症の分子標的治療薬としての潜在性.2014

    • Author(s)
      中田恵子, 駒野 淳.
    • Organizer
      第62回日本ウイルス学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-10 – 2014-11-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] 生物発光を利用した風疹ウイルス検出系の実験室診断への応用~流行要因解明に向けて~2014

    • Author(s)
      上林大起, 倉田貴子, 駒野 淳
    • Organizer
      第73回日本公衆衛生学会総会
    • Place of Presentation
      宇都宮.
    • Year and Date
      2014-11-05 – 2014-11-06
    • Related Report
      2014 Annual Research Report
  • [Presentation] Measles virus as a potential oncolytic virotherapy against B cell lymphomas.2014

    • Author(s)
      1)武田 哲, 上林大起, 倉田貴子, 吉山 裕樹, 駒野 淳.
    • Organizer
      第73回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2014-09-25 – 2014-09-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] Non-coding RNA(7SK)の転写抑制機能を模倣したRNAモチーフの探索2012

    • Author(s)
      山吉麻子, 岸本恭介, 林里依, 駒野淳, 小柳義夫, 小堀哲生, 村上章
    • Organizer
      第58回高分子研究発表会
    • Place of Presentation
      神戸
    • Year and Date
      2012-07-13
    • Related Report
      2012 Annual Research Report
  • [Presentation] 安全な細胞内免疫を可能にする治療分子の開発に関する研究2012

    • Author(s)
      駒野淳, 浦野恵美子, 宮内浩典, 市川玲子, 滝沢真理
    • Organizer
      第26回近畿エイズ研究会・学術集会
    • Place of Presentation
      神戸
    • Year and Date
      2012-01-07
    • Related Report
      2012 Annual Research Report
  • [Presentation] Toll-like receptor(TLR)3 as a potential sensor of retroviral nfection in human cell2012

    • Author(s)
      K Miyauchi, E Urano, S Takeda, T Murakami, Y Okada, K Cheng, H Yin, M Kubo, J Komano
    • Organizer
      CSHL meeting on Retroviruses
    • Place of Presentation
      Cold Spring Harbor, NY, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] P-TEFb複合体機能調節因子群によるHTLV-1転写制御メカニズムの解析2012

    • Author(s)
      浦野恵美子, 木村雄一, 駒野淳
    • Organizer
      第5回HTLV-1研究会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] Proliferative inhibition of ATL-derived and HTLV-1-transformed human Tcells by an artificial restriction2012

    • Author(s)
      駒野淳, 田中淳, 武田哲
    • Organizer
      第5回HTLV-1研究会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] A novel therapeutic molecule that irreversibly disrupts the HTLV-1 provirus2012

    • Author(s)
      J Komano, A Tanaka, S Takeda, R Ichikawa, E Urano
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌
    • Related Report
      2012 Annual Research Report
  • [Presentation] 再生医療によるHIV/AIDS遺伝子細胞治療法の開発に向けた技術基盤の構築2012

    • Author(s)
      武田哲, 駒野淳
    • Organizer
      第59回日本ウィルス学会学術集会
    • Place of Presentation
      大阪
    • Related Report
      2012 Annual Research Report
  • [Presentation] HTLV-1プロウイルスを物理的に傷害する人工酵素の開発2012

    • Author(s)
      駒野淳, 田中淳, 武田哲
    • Organizer
      第59回日本ウィルス学会学術集会
    • Place of Presentation
      大阪
    • Related Report
      2012 Annual Research Report
  • [Presentation] プロウイルスの物理的障害によるHTLV-1感染細胞増殖の抑制2012

    • Author(s)
      武田哲, 田中淳, 駒野淳
    • Organizer
      第59回日本ウイルス学会学術集会
    • Place of Presentation
      大阪
    • Related Report
      2012 Annual Research Report
  • [Presentation] HBV感染者における新規Ae/GリコンビナントHBVの解析2012

    • Author(s)
      小島洋子, 川畑拓也, 森治代, 駒野淳, 谷口恭, 井戸田一朗
    • Organizer
      第59回日本ウイルス学会学術集会
    • Place of Presentation
      大阪
    • Related Report
      2012 Annual Research Report
  • [Presentation] ヒト化マウスを用いたEBウイルス関連リンパ増殖性疾患に対する免疫細胞治療のモデル実験2012

    • Author(s)
      松田剛, 今留謙一, 矢島美彩子, 落合央, 望月雅司, 川野布由子, 山田千尋、今井由美, 濱崎霞, 浅田恵理子, 原口摩耶, 千葉祐規乃, 清水則夫, 駒野淳、, 山本直樹, 藤原成悦
    • Organizer
      第59回日本ウイルス学会学術集会
    • Place of Presentation
      大阪
    • Related Report
      2012 Annual Research Report
  • [Presentation] DNA J/HSP40 Co-chaperone familyによるHIV-1複製抑制メカニズムの解析2012

    • Author(s)
      駒野淳, 浦野恵美子
    • Organizer
      第25回日本エイズ学会学術集会・総会
    • Place of Presentation
      横浜
    • Related Report
      2012 Annual Research Report
  • [Presentation] 弱毒ワクシニアプライム、センダイウイルスブーストエイズワクチン法の免疫評価およびhCD40Lmアジュバント効果の検討2012

    • Author(s)
      張険峰, 祖父江友芳, 一色真央, 牧野俊, 井上誠, 加藤和則, 塩田達夫, 大橋貴, 駒野淳, 花房秀次, 志田壽利
    • Organizer
      第25回日本エイズ学会学術集会・総会
    • Place of Presentation
      横浜
    • Related Report
      2012 Annual Research Report
  • [Presentation] ペプチドミメティック型インテグラーゼ阻害剤の構造活性相関研究2012

    • Author(s)
      相川春夫, 松本大地, 野末愛美, 浦野恵美子, Mathieu Metifiot, Maddali Kasthuraiah, 野村渉, 鳴海哲夫, 駒野淳, 村上努, Pommier Yves, 山本直樹, 玉村啓和
    • Organizer
      第25回日本エイズ学会学術集会・総会
    • Place of Presentation
      横浜
    • Related Report
      2012 Annual Research Report
  • [Presentation] Therapeutic potential of an artificial endonuclease against HTLV-1 infection2012

    • Author(s)
      駒野淳, 武田哲, 田中淳
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡
    • Related Report
      2012 Annual Research Report
  • [Patent(Industrial Property Rights)] HIV立体構造認識抗体誘導ペプチド2012

    • Inventor(s)
      玉村啓和, 鳴海哲夫, 野村渉, 橋木知恵, 駒野淳, 宮内浩典,
    • Industrial Property Rights Holder
      玉村啓和, 鳴海哲夫, 野村渉, 橋木知恵, 駒野淳, 宮内浩典,
    • Filing Date
      2012-04-03
    • Related Report
      2012 Annual Research Report
    • Overseas

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Published: 2012-04-24   Modified: 2019-07-29  

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