Improvement of immune system by food components in visceral adipose tissues of diet-induced obese mice
| Project/Area Number |
24501024
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | National Agriculture and Food Research Organization |
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Principal Investigator |
KOBORI Masuko 独立行政法人農業・食品産業技術総合研究機構, 食品総合研究所・食品機能研究領域, 上席研究員 (50353941)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | ケルセチン / 肥満 / 内臓脂肪蓄積 / 免疫 / 内臓脂肪組織 |
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| Outline of Final Research Achievements |
Adipose tissue inflammation plays a pivotal role in the development of metabolic diseases. In this study, we examined the effect of quercetin on the accumulation and activation of immune cells in epididymal adipose tissues of a high fat, high sucrose and high cholesterol Western diet-induced obese mice. DNA microarray, RT-PCR and histological analyses showed that supplementation with quercetin suppressed the accumulation and activation of immune cells, such as macrophages, lymphocytes and mast cells, in the epididymal adipose tissues of mice fed a Western diet. Quercetin improved the ratio of CD4+/CD8+ T lymphocytes in mice fed a Western diet. Quercetin is suggested to suppress the inflammation through reducing the expression of TNFα and other inflammatory cytokines in the adipose tissues in diet-induced obese mice.
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Report
(4 results)
Research Products
(3 results)
