| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
Adipose tissue inflammation plays a pivotal role in the development of metabolic diseases. In this study, we examined the effect of quercetin on the accumulation and activation of immune cells in epididymal adipose tissues of a high fat, high sucrose and high cholesterol Western diet-induced obese mice. DNA microarray, RT-PCR and histological analyses showed that supplementation with quercetin suppressed the accumulation and activation of immune cells, such as macrophages, lymphocytes and mast cells, in the epididymal adipose tissues of mice fed a Western diet. Quercetin improved the ratio of CD4+/CD8+ T lymphocytes in mice fed a Western diet. Quercetin is suggested to suppress the inflammation through reducing the expression of TNFα and other inflammatory cytokines in the adipose tissues in diet-induced obese mice.
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