Role of unfolded protein response on age-related skeletal muscle atrophy
| Project/Area Number |
26350893
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied health science
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| Research Institution | The University of Tokushima |
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Principal Investigator |
MIYAKE Masato 徳島大学, 先端酵素学研究所(プロテオ), 助教 (30588976)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 小胞体 / 小胞体ストレス / 骨格筋 / 萎縮 / アミノ酸 / 筋萎縮 / PERK / ATF4 / 加齢 / インスリン感受性 / 分子シャペロン |
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| Outline of Final Research Achievements |
Unfolded protein response (UPR) is one of signal transduction pathway activated in endoplasmic reticulum (ER) respond to accumulation of unfolded proteins in ER lumen. In this study, we found that UPR is more activated in skeletal muscle of old mice than young mice. To understand the role of PERK pathway, one of the UPR signaling, we generated transgenic mouse that enable to control PERK signaling pathway This transgenic mouse showed muscle atrophy in young age after activation of PERK. Skeletal muscle of the transgenic mouse changed the amino acid metabolism compared with wild type mouse, especially branched-chain amino acids and anti-oxidant amino compounds. Overall, this study suggests that unfolded response modulate age-related skeletal muscle atrophy or sarcopenia.
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Report
(4 results)
Research Products
(16 results)
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[Journal Article] Skeletal muscle-specific eukaryotic translation initiation factor 2α phosphorylation controls amino acid metabolism and fibroblast growth factor 21-mediated non-cell-autonomous energy metabolism.2016
Author(s)
Miyake M, Nomura A, Ogura A, Takehana K, Kitahara Y, Takahara K, Tsugawa K, Miyamoto C, Miura N, Sato R, Kurahashi K, Harding HP, Oyadomari M, Ron D, Oyadomari S.
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Journal Title
FASEB journal
Volume: 30
Issue: 2
Pages: 798-812
DOI
NAID
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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