| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Outline of Final Research Achievements |
Unfolded protein response (UPR) is one of signal transduction pathway activated in endoplasmic reticulum (ER) respond to accumulation of unfolded proteins in ER lumen. In this study, we found that UPR is more activated in skeletal muscle of old mice than young mice. To understand the role of PERK pathway, one of the UPR signaling, we generated transgenic mouse that enable to control PERK signaling pathway This transgenic mouse showed muscle atrophy in young age after activation of PERK. Skeletal muscle of the transgenic mouse changed the amino acid metabolism compared with wild type mouse, especially branched-chain amino acids and anti-oxidant amino compounds. Overall, this study suggests that unfolded response modulate age-related skeletal muscle atrophy or sarcopenia.
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