Direct delivery of nitric oxide synthase isozyme improves heart failure in rats` myocardial infarction model.

• Project/Area Number: 21591802
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Thoracic surgery
• Research Institution: Wakayama Medical University
• Principal Investigator: HONDA Kentaro 和歌山県立医科大学, 医学部, 助教 (60508018)
• Co-Investigator(Kenkyū-buntansha): OKAMURA Yoshitaka 和歌山県立医科大学, 医学部, 教授 (80245076) ; MAEDA Masanobuz 和歌山県立医科大学, 医学部, 教授 (80181593) ; KOHSAKA Akira 和歌山県立医科大学, 医学部, 講師 (00458051) ; NISHIMURA Yoshiharu 和歌山県立医科大学, 医学部, 講師 (70254539) ; UCHITA Shunji 和歌山県立医科大学, 医学部, 講師 (10246556) ; 打田 俊司 和歌山県立医科大学, 医学部, 講師 (50508017)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2011: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000); Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 急性心筋梗塞 / 一酸化窒素合成酵素 / 心不全 / タンパク質導入 / タンパク質治療 / 一酸化窒素合成酵 / アイソザイム / 蛋白質 / 蛋白質治療

Research Abstract

It was successful that direct delivery of nitric oxide synthase(NOS) isozymes into myocardium in acute myocardial infarction rat model. The direct delivery of NOS reduced the size of infarcted area in acute phase after acute myocardial infarction. And then the direct delivery NOS of improved cardiac function.

Research Products

• [Presentation] Direct transduction of vascular endothelial growth factor into cardiomyocytes reduced infarcted areas in acute myocardial infarction rats (2010)
  • Author(s): Masahiro Kaneko, Atsutoshi Hatada, Yoshiharu Nishimura, Shunji Uchita, Koji Toguchi, Kentaro Honda, Takeo Nakai, Hidefumi Waki, Akira Kohsaka, Yoshitaka Okamura, Masanobu Maeda
  • Organizer: 第87回日本生理学会
  • Place of Presentation: 盛岡
• [Presentation] Direct transduction of vascular endothelial growth factor into cardiomyo cytes reduced infarcted areas in acute myocardial infarction rats (2010)
  • Author(s): Masahiro Kaneko, Atsutoshi Hatada, Yoshiharu Nishimura, Shunji Uchita, Koji Toguchi, Kentaro Honda, Takeo Nakai, Hidefumi Waki, Akira Kohsaka, Yoshitaka Okamura, Masano bu Maeda
  • Organizer: 第87回日本生理学会
  • Place of Presentation: 盛岡