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Direct delivery of nitric oxide synthase isozyme improves heart failure in rats` myocardial infarction model.

Research Project

Project/Area Number 21591802
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Thoracic surgery
Research InstitutionWakayama Medical University

Principal Investigator

HONDA Kentaro  和歌山県立医科大学, 医学部, 助教 (60508018)

Co-Investigator(Kenkyū-buntansha) OKAMURA Yoshitaka  和歌山県立医科大学, 医学部, 教授 (80245076)
MAEDA Masanobuz  和歌山県立医科大学, 医学部, 教授 (80181593)
KOHSAKA Akira  和歌山県立医科大学, 医学部, 講師 (00458051)
NISHIMURA Yoshiharu  和歌山県立医科大学, 医学部, 講師 (70254539)
UCHITA Shunji  和歌山県立医科大学, 医学部, 講師 (10246556)
打田 俊司  和歌山県立医科大学, 医学部, 講師 (50508017)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords急性心筋梗塞 / 一酸化窒素合成酵素 / 心不全 / タンパク質導入 / タンパク質治療 / 一酸化窒素合成酵 / アイソザイム / 蛋白質 / 蛋白質治療
Research Abstract

It was successful that direct delivery of nitric oxide synthase(NOS) isozymes into myocardium in acute myocardial infarction rat model. The direct delivery of NOS reduced the size of infarcted area in acute phase after acute myocardial infarction. And then the direct delivery NOS of improved cardiac function.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (2 results)

All 2010

All Presentation (2 results)

  • [Presentation] Direct transduction of vascular endothelial growth factor into cardiomyocytes reduced infarcted areas in acute myocardial infarction rats2010

    • Author(s)
      Masahiro Kaneko, Atsutoshi Hatada, Yoshiharu Nishimura, Shunji Uchita, Koji Toguchi, Kentaro Honda, Takeo Nakai, Hidefumi Waki, Akira Kohsaka, Yoshitaka Okamura, Masanobu Maeda
    • Organizer
      第87回日本生理学会
    • Place of Presentation
      盛岡
    • Related Report
      2011 Final Research Report
  • [Presentation] Direct transduction of vascular endothelial growth factor into cardiomyo cytes reduced infarcted areas in acute myocardial infarction rats2010

    • Author(s)
      Masahiro Kaneko, Atsutoshi Hatada, Yoshiharu Nishimura, Shunji Uchita, Koji Toguchi, Kentaro Honda, Takeo Nakai, Hidefumi Waki, Akira Kohsaka, Yoshitaka Okamura, Masano bu Maeda
    • Organizer
      第87回日本生理学会
    • Place of Presentation
      盛岡
    • Related Report
      2010 Annual Research Report

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Published: 2009-04-01   Modified: 2018-02-02  

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