KAKEN — Research Projects | Researcher Number: 90142942

1. Finite element analysis of thoracic aortic aneurysm and prediction of rupture: Application after TEVAR

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Thoracic surgery
Research Institution	Tohoku University
Principal Investigator	KUMAGAI Kiichiro 東北大学, 大学院・医学系研究科, 助教
Project Period (FY)	2010 – 2012Completed
Keywords	胸部大動脈瘤 / 有限要素法 / ステントグラフト / 大動脈解離 / 有限要素解析
Research Abstract	To predict rupture potential risk for patients with thoracic aortic aneurysm, we calculated the maximal von Mises stress (Max VMS) of finite element m ...

Research Products of this project	Presentation (4 results)

2. The Clinical Trial of Novel Biodegradable External Film Releasing Rapamycin for CABG

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Thoracic surgery
Research Institution	Tohoku University
Principal Investigator	ODA Katsuhiko 東北大学, 大学院・医学系研究科, 非常勤講師
Project Period (FY)	2010 – 2012Completed
Keywords	Drug-delivery system / 循環器 / 心臓外科 / 臨床 / 虚血性心疾患 / 循環器・高血圧 / 冠動脈バイパス手術 / 吻合部狭窄 / 内膜肥厚 / ＤＤＳ
Research Abstract	To develop a novel technology to prevent saphenous vein grafts stenosis in CABG, the clinical trial of external application of rapamycin-eluting film ...

Research Products of this project	Presentation (2 results)

3. Elucidation of the mechanism of perioperative kidney injury and establishment of the new strategy of kidney protection in Cardiovascular surgery.

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Thoracic surgery
Research Institution	Tohoku University
Principal Investigator	MOTOYOSHI Naotaka 東北大学, 病院, 講師
Project Period (FY)	2009 – 2011Completed
Keywords	心臓大血管外科 / 腎障害 / 腎保護 / 腎虚血再灌流障害 / PPAR-γ / LXR-α
Research Abstract	We have established the porcine renal ischemia-reperfusion injury model clamping bilateral renal arteries. Then, we assessed the degrees of kidney dam ...

4. Biodegradable stent of external wrapping with autologous vein grafts prevents graft stenosis at long term in a canine model

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Thoracic surgery
Research Institution	Tohoku University
Principal Investigator	IGUCHI Atsushi 東北大学, 大学院・医学系研究科, 非常勤講師
Project Period (FY)	2009 – 2011Completed
Keywords	冠動脈バイパス / ステント / 生体吸収性素材 / 再生医学 / 冠動脈バイパス術
Research Abstract	In the CABG surgery, autologous vein graft stenosis and occlusion at long term has been a significant clinical issue. It was said that reduction of th ...

5. The development of novel therapy for cardiac allograft vasculopathy after heart transplantation to modulate the proteoglycans formation

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Thoracic surgery
Research Institution	Tohoku University
Principal Investigator	KAWAMOTO Shunsuke 東北大学, 大学院・医学系研究科, 准教授
Project Period (FY)	2009 – 2011Completed
Keywords	移植・再生 / 循環器・高血圧 / 細胞外マトリックス / 遺伝子治療 / 移植・再生医療
Research Abstract	Focusing on overproduced proteoglycans as major components of extracellular matrix in the cardiac allograft vasculopathy after heart transplantation, ...

6. Development of oxygen saturation analysis system applicable to deep solid organs

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Thoracic surgery
Research Institution	Tohoku University
Principal Investigator	SAIKI Yoshikatsu Tohoku University
Project Period (FY)	2008 – 2010Completed
Keywords	心臓大血管外科 / 生物・生体工学 / ナノマシン / 臓器虚血 / 酸素飽和度 / マイクロ・ナノテクノロジー / 充実性臓器 / マイクロフォトディテクター / 光ファイバ / 光フアイバ
Research Abstract	We attempted to invent a microphotodetector system to enable us to monitor oxygen saturation on the solid organs located away deep from the body surfa ...

Research Products of this project	Remarks (1 results)

7. Epidermal cooling for spinal cord protection against ischemia

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Thoracic surgery
Research Institution	Tohoku University
Principal Investigator	TABAYASHI Koichi Tohoku University
Project Period (FY)	2008 – 2010Completed
Keywords	心臓大血管外科学 / 神経保護 / 脊髄保護 / 局所冷却
Research Abstract	Epidermal cooling may bring protective effect against ischemia on deep tissue such as spinal cord which can be suffered from ischemia during clinical ...

Research Products of this project	Journal Article (4 results, of which Peer Reviewed: 4 results) Remarks (1 results)

8. Development of a passive-active artificialmyocardium reconcilingthe physiological demands with hemodynamic changes

Research Project

Research Category	Grant-in-Aid for Young Scientists (A)
Research Field	Thoracic surgery
Research Institution	Tohoku University
Principal Investigator	SHIRAISHI Yasuyuki Tohoku University
Project Period (FY)	2007 – 2009Completed
Keywords	心不全 / 循環補助 / 人工心筋 / 適合制御 / 形状記憶合金線維
Research Abstract	We developed a sophisticated artificial myocardium which consisted of shape memory alloy fibre units. We applied the PID method for the control of myo ...

Research Products of this project	Journal Article (48 results, of which Peer Reviewed: 42 results) Presentation (68 results) Book (4 results) Remarks (4 results) Patent(Industrial Property Rights) (1 results)

9. Development of a novel monitoring system for spinal cord ischemia

Research Project

Research Category	Grant-in-Aid for Scientific Research (B)
Research Field	Thoracic surgery
Research Institution	Tohoku University
Principal Investigator	SAI Sadahiro Tohoku University
Project Period (FY)	2007 – 2010Completed
Keywords	心臓大血管外科 / 生物・生体工学 / ナノマシン / 脊髄虚血 / 胸腹部大動脈瘤
Research Abstract	We created a novel device consisted of micro-flow sensor element and transmitting/receiving circuit to detect spinal cord ischemia. The sensor unit co ...

Research Products of this project	Journal Article (3 results, of which Peer Reviewed: 1 results) Presentation (4 results) Remarks (1 results) Patent(Industrial Property Rights) (2 results, of which Overseas: 1 results)

10. 心血管系組織再生を目指した生体内バイオリアクターの開発

Research Project

Research Category	Grant-in-Aid for Exploratory Research
Research Field	Thoracic surgery
Research Institution	Tohoku University
Principal Investigator	川本俊輔 Tohoku University
Project Period (FY)	2006 – 2008Completed
Keywords	再生医学 / バイオリクター / 循環器・高血圧 / バイオリアクター
Research Abstract	本年度は、昨年度までの実験結果をもとに、ビーグル犬を用いて本格的な実験を開始した。まず、ビーグル犬の背部皮下を剥離し、体外式心臓用ペースメーカーと刺激電極を用いて広背筋と肋間筋で、筋肉刺激モデルを確立した。

11. Analysis of chronic rejection after heart transplantation, possible involvement of Toll-like receptor.

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Thoracic surgery
Research Institution	Tohoku University
Principal Investigator	AKAWAKA Junitsu Tohoku University
Project Period (FY)	2006 – 2008Completed
Keywords	Toll-like receptor / 心臓移植 / 冠動脈硬化 / 虚血再灌流障害 / interleikin-1 beta / Toll-like receotr / interleukin-1 beta / TNF-alpha / interleukin-10
Research Abstract	虚血再灌流障害にたいするToll-like receptorの関与を検索するために大動物を用いた実験を行なった.15-18kgのブタをドナーおよびレシピエントとして人工心肺下に同所性心臓移植を行なった.大動脈遮断、6時間の心保存ののち再灌流後、2時間で心筋の標本を採取した。形態学的な検索として、po ...

12. The inhaled slow-released vessel growth factor delivery system using gelatin hydrogel microspheres

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Thoracic surgery
Research Institution	Tohoku University
Principal Investigator	NITTA Yoshio Tohoku University, Tohoku University Hospital, Assistant Professor
Project Period (FY)	2005 – 2007Completed
Keywords	slow-released / vessel growth factor / inhaled drug / pulmonary artery bed / Fontan
Research Abstract	[Background] The Fontan type right heart bypass surgery is a useful functional repair method for single ventricle type congenital heart diseases. Howe ...

13. Experimental study of the mechanism that smoking can cause aneurismal change in the aorta

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Thoracic surgery
Research Institution	Tohoku University
Principal Investigator	SAIKI Yoshikatsu Tohoku University, Tohoku University Hospital, Lecturer
Project Period (FY)	2005 – 2007Completed
Keywords	Smoking / Aortic aneurysm / Drug delivery system
Research Abstract	The heavy smokers have more potential risk of enlargement of aortic wall than non-smoker etiologically. Thus our purpose is to analyze the mechanism t ...

14. New treatment for acute pulmonary artery hypertension to ameliorate postoperative right heart failure

Research Project

Research Category	Grant-in-Aid for Scientific Research (B)
Research Field	Thoracic surgery
Research Institution	Tohoku University
Principal Investigator	IGUCHI Atushi Tohoku University, Graduate School of Medicien, Associate Professor
Project Period (FY)	2005 – 2007Completed
Keywords	pulmonary hypertension / heart transplantation / PDE inhibitor / Nitric oxide / Sildenafil / right ventricular function / Iloprost / shunt
Research Abstract	Pigs weighing 14-18 kg were used for this experimental study. The animals were treated with either 20-40ppm of inhaled nitric oxide (NO) or 60 maicrog ...

15. 骨髄幹細房誘導による人工血管感染の治療

Research Project

Research Category	Grant-in-Aid for Exploratory Research
Research Field	Thoracic surgery
Research Institution	Tohoku University
Principal Investigator	田林晄一東北大学, 大学院・医学系研究科, 教授
Project Period (FY)	2003 – 2005Completed
Keywords	人工血管感染 / 胸部大動脈瘤 / 骨髄幹細胞 / 徐放性 / ゼラチン / bFGF / G-CSF / 縦隔炎 / 細菌感染 / 骨髄幹細胞誘導 / VEGF / アデノウィルスベクター
Research Abstract	胸部大動脈瘤の手術治療成績は近年向上し、破裂死亡の減少に大きく寄与していると考えられるが、未解決の術後合併症も依然少なくない。特に人工血管感染は、重篤かつ治療に難渋する合併症で、敗血症、多臓器不全、吻合部破裂に至り、救命し得ないことが多い。

Research Products of this project	Journal Article (4 results)

16. Quantitative evaluation of local biomechanics of thoracic aorta

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Thoracic surgery
Research Institution	Tohoku University
Principal Investigator	SAI Sadahiro Tohoku University, Hospital, Lecturer
Project Period (FY)	2003 – 2004Completed
Keywords	Aortic aneurysm / Biomechanics / Intravascular ultrasound / Transesophageal echocardiography / Vascular wall / Tissue velocity / Macrophage / Inflammation
Research Abstract	The objectives of the present study are to develop a quantitative measurement system of biomechanics of aortic wall by applying ultrasound diagnostics ...

Research Products of this project	Journal Article (11 results) Book (2 results) Publications (7 results)

17. The effect of new drug delivery method on ventricular function after heart transplantation from non-heart-beating donors.

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Thoracic surgery
Research Institution	Tohoku University
Principal Investigator	IGUCHI Atsushi Tohoku University, Gradate School of Medicine, Associate Professor
Project Period (FY)	2003 – 2004Completed
Keywords	non-heart-beating donor / heart transplantation / conductance catheter / pressure-volume relation / left ventricular function / right ventricular function / ischemia reperfusion injury / sodium / hydrogen exchange
Research Abstract	The purpose of present study was to elucidate the side effects and optimal timing and delivery method of Na(+)/H(+) exchange inhibitor (NHEI). Effect ...

18. Gene therapy for spinal code protection

Research Project

Research Category	Grant-in-Aid for Scientific Research (B)
Research Field	Thoracic surgery
Research Institution	Tohoku University
Principal Investigator	TABAYASHI Koichi Tohoku University, Graduate School of Medicine, Professor
Project Period (FY)	2002 – 2004Completed
Keywords	spinal cord protection / thoracic aneurysm / gene therapy / paraplegia / ORP150 / CAG promoter / adenoviral vector / lipofection
Research Abstract	Spinal cord injury after successful aortic surgical operations is an unacceptable complication for patients, and new spinal cord protection method is ...

Research Products of this project	Journal Article (28 results)

19. Establishment of Tissue Banking System on the basis of regional linkage

Research Project

Research Category	Grant-in-Aid for University and Society Collaboration
Research Field	Thoracic surgery
Research Institution	The University of Tokyo
Principal Investigator	TAKAMOTO Shinichi Cardiac Surgery, Professor
Project Period (FY)	2000 – 2002Completed
Keywords	Allograft tissue / Cryopreservation / Tissue transplantation / Tissue bank / Network
Research Abstract	1. Founding the Network for allograft tissue procurement

Research Products of this project	Publications (61 results)

20. 吸収性素材を用いた心膜再建に関する実験的研究

Research Project

Research Category	Grant-in-Aid for Exploratory Research
Research Field	Thoracic surgery
Research Institution	Tohoku University
Principal Investigator	田林晄一東北大学, 大学院・医学系研究科, 教授
Project Period (FY)	1999 – 2000Completed
Keywords	代用心膜 / ゼラチン / ゴアテックス / カプロラクトン / 吸収性素材 / 心臓癒着 / 心膜 / 乳酸-カプロラクトン共重合体 / ポリテトラフルオロエチレン
Research Abstract	目的:本研究の目的は心膜の代用物として吸収性素材である架橋ゼラチンシート、乳酸-カプロラクトン共重合体シートを用い,術後遠隔期の癒着の程度をexpanded-polytetra-fluoroethylene(e-PTFE)シート,自己心膜で閉鎖した群と比較することにある。平成11年、12年度中に以下 ...

Research Products of this project	Publications (3 results)

Project Period (Start Year [FY])

1. Finite element analysis of thoracic aortic aneurysm and prediction of rupture: Application after TEVAR Research Project

KUMAGAI Kiichiro 東北大学, 大学院・医学系研究科, 助教

2. The Clinical Trial of Novel Biodegradable External Film Releasing Rapamycin for CABG Research Project

ODA Katsuhiko 東北大学, 大学院・医学系研究科, 非常勤講師

3. Elucidation of the mechanism of perioperative kidney injury and establishment of the new strategy of kidney protection in Cardiovascular surgery. Research Project

MOTOYOSHI Naotaka 東北大学, 病院, 講師

4. Biodegradable stent of external wrapping with autologous vein grafts prevents graft stenosis at long term in a canine model Research Project

IGUCHI Atsushi 東北大学, 大学院・医学系研究科, 非常勤講師

5. The development of novel therapy for cardiac allograft vasculopathy after heart transplantation to modulate the proteoglycans formation Research Project

KAWAMOTO Shunsuke 東北大学, 大学院・医学系研究科, 准教授

6. Development of oxygen saturation analysis system applicable to deep solid organs Research Project

SAIKI Yoshikatsu Tohoku University

7. Epidermal cooling for spinal cord protection against ischemia Research Project

TABAYASHI Koichi Tohoku University

8. Development of a passive-active artificialmyocardium reconcilingthe physiological demands with hemodynamic changes Research Project

SHIRAISHI Yasuyuki Tohoku University

9. Development of a novel monitoring system for spinal cord ischemia Research Project

SAI Sadahiro Tohoku University

10. 心血管系組織再生を目指した生体内バイオリアクターの開発 Research Project

川本 俊輔 Tohoku University

11. Analysis of chronic rejection after heart transplantation, possible involvement of Toll-like receptor. Research Project

AKAWAKA Junitsu Tohoku University

12. The inhaled slow-released vessel growth factor delivery system using gelatin hydrogel microspheres Research Project

NITTA Yoshio Tohoku University, Tohoku University Hospital, Assistant Professor

13. Experimental study of the mechanism that smoking can cause aneurismal change in the aorta Research Project

SAIKI Yoshikatsu Tohoku University, Tohoku University Hospital, Lecturer

14. New treatment for acute pulmonary artery hypertension to ameliorate postoperative right heart failure Research Project

IGUCHI Atushi Tohoku University, Graduate School of Medicien, Associate Professor

15. 骨髄幹細房誘導による人工血管感染の治療 Research Project

田林 晄一 東北大学, 大学院・医学系研究科, 教授

16. Quantitative evaluation of local biomechanics of thoracic aorta Research Project

SAI Sadahiro Tohoku University, Hospital, Lecturer

17. The effect of new drug delivery method on ventricular function after heart transplantation from non-heart-beating donors. Research Project

IGUCHI Atsushi Tohoku University, Gradate School of Medicine, Associate Professor

18. Gene therapy for spinal code protection Research Project

TABAYASHI Koichi Tohoku University, Graduate School of Medicine, Professor

19. Establishment of Tissue Banking System on the basis of regional linkage Research Project

TAKAMOTO Shinichi Cardiac Surgery, Professor

20. 吸収性素材を用いた心膜再建に関する実験的研究 Research Project

田林 晄一 東北大学, 大学院・医学系研究科, 教授

1. Finite element analysis of thoracic aortic aneurysm and prediction of rupture: Application after TEVAR

Research Project

2. The Clinical Trial of Novel Biodegradable External Film Releasing Rapamycin for CABG

Research Project

3. Elucidation of the mechanism of perioperative kidney injury and establishment of the new strategy of kidney protection in Cardiovascular surgery.

Research Project

4. Biodegradable stent of external wrapping with autologous vein grafts prevents graft stenosis at long term in a canine model

Research Project

5. The development of novel therapy for cardiac allograft vasculopathy after heart transplantation to modulate the proteoglycans formation

Research Project

6. Development of oxygen saturation analysis system applicable to deep solid organs

Research Project

7. Epidermal cooling for spinal cord protection against ischemia

Research Project

8. Development of a passive-active artificialmyocardium reconcilingthe physiological demands with hemodynamic changes

Research Project

9. Development of a novel monitoring system for spinal cord ischemia

Research Project

10. 心血管系組織再生を目指した生体内バイオリアクターの開発

Research Project

川本俊輔 Tohoku University

11. Analysis of chronic rejection after heart transplantation, possible involvement of Toll-like receptor.

Research Project

12. The inhaled slow-released vessel growth factor delivery system using gelatin hydrogel microspheres

Research Project

13. Experimental study of the mechanism that smoking can cause aneurismal change in the aorta

Research Project

14. New treatment for acute pulmonary artery hypertension to ameliorate postoperative right heart failure

Research Project

15. 骨髄幹細房誘導による人工血管感染の治療

Research Project

田林晄一東北大学, 大学院・医学系研究科, 教授

16. Quantitative evaluation of local biomechanics of thoracic aorta

Research Project

17. The effect of new drug delivery method on ventricular function after heart transplantation from non-heart-beating donors.

Research Project

18. Gene therapy for spinal code protection

Research Project

19. Establishment of Tissue Banking System on the basis of regional linkage

Research Project

20. 吸収性素材を用いた心膜再建に関する実験的研究

Research Project

田林晄一東北大学, 大学院・医学系研究科, 教授