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Search Results: 35 results / Researcher Number: 90142942

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  • 1. Finite element analysis of thoracic aortic aneurysm and prediction of rupture: Application after TEVAR

    Research Project

    Research Category

    Grant-in-Aid for Scientific Research (C)

    Research Field Thoracic surgery
    Research Institution Tohoku University
    Principal Investigator

    KUMAGAI Kiichiro 東北大学, 大学院・医学系研究科, 助教

    Project Period (FY) 2010 – 2012Completed
    Keywords 胸部大動脈瘤 / 有限要素法 / ステントグラフト / 大動脈解離 / 有限要素解析
    Research Abstract To predict rupture potential risk for patients with thoracic aortic aneurysm, we calculated the maximal von Mises stress (Max VMS) of finite element m ...
    Research Products of this project Presentation (4 results)
  • 2. The Clinical Trial of Novel Biodegradable External Film Releasing Rapamycin for CABG

    Research Project

    Research Category

    Grant-in-Aid for Scientific Research (C)

    Research Field Thoracic surgery
    Research Institution Tohoku University
    Principal Investigator

    ODA Katsuhiko 東北大学, 大学院・医学系研究科, 非常勤講師

    Project Period (FY) 2010 – 2012Completed
    Keywords Drug-delivery system / 循環器 / 心臓外科 / 臨床 / 虚血性心疾患 / 循環器・高血圧 / 冠動脈バイパス手術 / 吻合部狭窄 / 内膜肥厚 / DDS
    Research Abstract To develop a novel technology to prevent saphenous vein grafts stenosis in CABG, the clinical trial of external application of rapamycin-eluting film  ...
    Research Products of this project Presentation (2 results)
  • 3. Elucidation of the mechanism of perioperative kidney injury and establishment of the new strategy of kidney protection in Cardiovascular surgery.

    Research Project

    Research Category

    Grant-in-Aid for Scientific Research (C)

    Research Field Thoracic surgery
    Research Institution Tohoku University
    Principal Investigator

    MOTOYOSHI Naotaka 東北大学, 病院, 講師

    Project Period (FY) 2009 – 2011Completed
    Keywords 心臓大血管外科 / 腎障害 / 腎保護 / 腎虚血再灌流障害 / PPAR-γ / LXR-α
    Research Abstract We have established the porcine renal ischemia-reperfusion injury model clamping bilateral renal arteries. Then, we assessed the degrees of kidney dam ...
  • 4. Biodegradable stent of external wrapping with autologous vein grafts prevents graft stenosis at long term in a canine model

    Research Project

    Research Category

    Grant-in-Aid for Scientific Research (C)

    Research Field Thoracic surgery
    Research Institution Tohoku University
    Principal Investigator

    IGUCHI Atsushi 東北大学, 大学院・医学系研究科, 非常勤講師

    Project Period (FY) 2009 – 2011Completed
    Keywords 冠動脈バイパス / ステント / 生体吸収性素材 / 再生医学 / 冠動脈バイパス術
    Research Abstract In the CABG surgery, autologous vein graft stenosis and occlusion at long term has been a significant clinical issue. It was said that reduction of th ...
  • 5. The development of novel therapy for cardiac allograft vasculopathy after heart transplantation to modulate the proteoglycans formation

    Research Project

    Research Category

    Grant-in-Aid for Scientific Research (C)

    Research Field Thoracic surgery
    Research Institution Tohoku University
    Principal Investigator

    KAWAMOTO Shunsuke 東北大学, 大学院・医学系研究科, 准教授

    Project Period (FY) 2009 – 2011Completed
    Keywords 移植・再生 / 循環器・高血圧 / 細胞外マトリックス / 遺伝子治療 / 移植・再生医療
    Research Abstract Focusing on overproduced proteoglycans as major components of extracellular matrix in the cardiac allograft vasculopathy after heart transplantation,  ...
  • 6. Development of oxygen saturation analysis system applicable to deep solid organs

    Research Project

    Research Category

    Grant-in-Aid for Scientific Research (C)

    Research Field Thoracic surgery
    Research Institution Tohoku University
    Principal Investigator

    SAIKI Yoshikatsu Tohoku University

    Project Period (FY) 2008 – 2010Completed
    Keywords 心臓大血管外科 / 生物・生体工学 / ナノマシン / 臓器虚血 / 酸素飽和度 / マイクロ・ナノテクノロジー / 充実性臓器 / マイクロフォトディテクター / 光ファイバ / 光フアイバ
    Research Abstract We attempted to invent a microphotodetector system to enable us to monitor oxygen saturation on the solid organs located away deep from the body surfa ...
    Research Products of this project Remarks (1 results)
  • 7. Epidermal cooling for spinal cord protection against ischemia

    Research Project

    Research Category

    Grant-in-Aid for Scientific Research (C)

    Research Field Thoracic surgery
    Research Institution Tohoku University
    Principal Investigator

    TABAYASHI Koichi Tohoku University

    Project Period (FY) 2008 – 2010Completed
    Keywords 心臓大血管外科学 / 神経保護 / 脊髄保護 / 局所冷却
    Research Abstract Epidermal cooling may bring protective effect against ischemia on deep tissue such as spinal cord which can be suffered from ischemia during clinical  ...
    Research Products of this project Journal Article (4 results, of which Peer Reviewed: 4 results)   Remarks (1 results)
  • 8. Development of a passive-active artificialmyocardium reconcilingthe physiological demands with hemodynamic changes

    Research Project

    Research Category

    Grant-in-Aid for Young Scientists (A)

    Research Field Thoracic surgery
    Research Institution Tohoku University
    Principal Investigator

    SHIRAISHI Yasuyuki Tohoku University

    Project Period (FY) 2007 – 2009Completed
    Keywords 心不全 / 循環補助 / 人工心筋 / 適合制御 / 形状記憶合金線維
    Research Abstract We developed a sophisticated artificial myocardium which consisted of shape memory alloy fibre units. We applied the PID method for the control of myo ...
    Research Products of this project Journal Article (48 results, of which Peer Reviewed: 42 results)   Presentation (68 results)   Book (4 results)   Remarks (4 results)   Patent(Industrial Property Rights) (1 results)
  • 9. Development of a novel monitoring system for spinal cord ischemia

    Research Project

    Research Category

    Grant-in-Aid for Scientific Research (B)

    Research Field Thoracic surgery
    Research Institution Tohoku University
    Principal Investigator

    SAI Sadahiro Tohoku University

    Project Period (FY) 2007 – 2010Completed
    Keywords 心臓大血管外科 / 生物・生体工学 / ナノマシン / 脊髄虚血 / 胸腹部大動脈瘤
    Research Abstract We created a novel device consisted of micro-flow sensor element and transmitting/receiving circuit to detect spinal cord ischemia. The sensor unit co ...
    Research Products of this project Journal Article (3 results, of which Peer Reviewed: 1 results)   Presentation (4 results)   Remarks (1 results)   Patent(Industrial Property Rights) (2 results, of which Overseas: 1 results)
  • 10. 心血管系組織再生を目指した生体内バイオリアクターの開発

    Research Project

    Research Category

    Grant-in-Aid for Exploratory Research

    Research Field Thoracic surgery
    Research Institution Tohoku University
    Principal Investigator

    川本 俊輔 Tohoku University

    Project Period (FY) 2006 – 2008Completed
    Keywords 再生医学 / バイオリクター / 循環器・高血圧 / バイオリアクター
    Research Abstract 本年度は、昨年度までの実験結果をもとに、ビーグル犬を用いて本格的な実験を開始した。まず、ビーグル犬の背部皮下を剥離し、体外式心臓用ペースメーカーと刺激電極を用いて広背筋と肋間筋で、筋肉刺激モデルを確立した。
  • 11. Analysis of chronic rejection after heart transplantation, possible involvement of Toll-like receptor.

    Research Project

    Research Category

    Grant-in-Aid for Scientific Research (C)

    Research Field Thoracic surgery
    Research Institution Tohoku University
    Principal Investigator

    AKAWAKA Junitsu Tohoku University

    Project Period (FY) 2006 – 2008Completed
    Keywords Toll-like receptor / 心臓移植 / 冠動脈硬化 / 虚血再灌流障害 / interleikin-1 beta / Toll-like receotr / interleukin-1 beta / TNF-alpha / interleukin-10
    Research Abstract 虚血再灌流障害にたいするToll-like receptorの関与を検索するために大動物を用いた実験を行なった.15-18kgのブタをドナーおよびレシピエントとして人工心肺下に同所性心臓移植を行なった.大動脈遮断、6時間の心保存ののち再灌流後、2時間で心筋の標本を採取した。形態学的な検索として、po ...
  • 12. The inhaled slow-released vessel growth factor delivery system using gelatin hydrogel microspheres

    Research Project

    Research Category

    Grant-in-Aid for Scientific Research (C)

    Research Field Thoracic surgery
    Research Institution Tohoku University
    Principal Investigator

    NITTA Yoshio Tohoku University, Tohoku University Hospital, Assistant Professor

    Project Period (FY) 2005 – 2007Completed
    Keywords slow-released / vessel growth factor / inhaled drug / pulmonary artery bed / Fontan
    Research Abstract [Background] The Fontan type right heart bypass surgery is a useful functional repair method for single ventricle type congenital heart diseases. Howe ...
  • 13. Experimental study of the mechanism that smoking can cause aneurismal change in the aorta

    Research Project

    Research Category

    Grant-in-Aid for Scientific Research (C)

    Research Field Thoracic surgery
    Research Institution Tohoku University
    Principal Investigator

    SAIKI Yoshikatsu Tohoku University, Tohoku University Hospital, Lecturer

    Project Period (FY) 2005 – 2007Completed
    Keywords Smoking / Aortic aneurysm / Drug delivery system
    Research Abstract The heavy smokers have more potential risk of enlargement of aortic wall than non-smoker etiologically. Thus our purpose is to analyze the mechanism t ...
  • 14. New treatment for acute pulmonary artery hypertension to ameliorate postoperative right heart failure

    Research Project

    Research Category

    Grant-in-Aid for Scientific Research (B)

    Research Field Thoracic surgery
    Research Institution Tohoku University
    Principal Investigator

    IGUCHI Atushi Tohoku University, Graduate School of Medicien, Associate Professor

    Project Period (FY) 2005 – 2007Completed
    Keywords pulmonary hypertension / heart transplantation / PDE inhibitor / Nitric oxide / Sildenafil / right ventricular function / Iloprost / shunt
    Research Abstract Pigs weighing 14-18 kg were used for this experimental study. The animals were treated with either 20-40ppm of inhaled nitric oxide (NO) or 60 maicrog ...
  • 15. 骨髄幹細房誘導による人工血管感染の治療

    Research Project

    Research Category

    Grant-in-Aid for Exploratory Research

    Research Field Thoracic surgery
    Research Institution Tohoku University
    Principal Investigator

    田林 晄一 東北大学, 大学院・医学系研究科, 教授

    Project Period (FY) 2003 – 2005Completed
    Keywords 人工血管感染 / 胸部大動脈瘤 / 骨髄幹細胞 / 徐放性 / ゼラチン / bFGF / G-CSF / 縦隔炎 / 細菌感染 / 骨髄幹細胞誘導 / VEGF / アデノウィルスベクター
    Research Abstract 胸部大動脈瘤の手術治療成績は近年向上し、破裂死亡の減少に大きく寄与していると考えられるが、未解決の術後合併症も依然少なくない。特に人工血管感染は、重篤かつ治療に難渋する合併症で、敗血症、多臓器不全、吻合部破裂に至り、救命し得ないことが多い。
    Research Products of this project Journal Article (4 results)
  • 16. Quantitative evaluation of local biomechanics of thoracic aorta

    Research Project

    Research Category

    Grant-in-Aid for Scientific Research (C)

    Research Field Thoracic surgery
    Research Institution Tohoku University
    Principal Investigator

    SAI Sadahiro Tohoku University, Hospital, Lecturer

    Project Period (FY) 2003 – 2004Completed
    Keywords Aortic aneurysm / Biomechanics / Intravascular ultrasound / Transesophageal echocardiography / Vascular wall / Tissue velocity / Macrophage / Inflammation
    Research Abstract The objectives of the present study are to develop a quantitative measurement system of biomechanics of aortic wall by applying ultrasound diagnostics ...
    Research Products of this project Journal Article (11 results)   Book (2 results)   Publications (7 results)
  • 17. The effect of new drug delivery method on ventricular function after heart transplantation from non-heart-beating donors.

    Research Project

    Research Category

    Grant-in-Aid for Scientific Research (C)

    Research Field Thoracic surgery
    Research Institution Tohoku University
    Principal Investigator

    IGUCHI Atsushi Tohoku University, Gradate School of Medicine, Associate Professor

    Project Period (FY) 2003 – 2004Completed
    Keywords non-heart-beating donor / heart transplantation / conductance catheter / pressure-volume relation / left ventricular function / right ventricular function / ischemia reperfusion injury / sodium / hydrogen exchange
    Research Abstract The purpose of present study was to elucidate the side effects and optimal timing and delivery method of Na(+)/H(+) exchange inhibitor (NHEI). Effect  ...
  • 18. Gene therapy for spinal code protection

    Research Project

    Research Category

    Grant-in-Aid for Scientific Research (B)

    Research Field Thoracic surgery
    Research Institution Tohoku University
    Principal Investigator

    TABAYASHI Koichi Tohoku University, Graduate School of Medicine, Professor

    Project Period (FY) 2002 – 2004Completed
    Keywords spinal cord protection / thoracic aneurysm / gene therapy / paraplegia / ORP150 / CAG promoter / adenoviral vector / lipofection
    Research Abstract Spinal cord injury after successful aortic surgical operations is an unacceptable complication for patients, and new spinal cord protection method is  ...
    Research Products of this project Journal Article (28 results)
  • 19. Establishment of Tissue Banking System on the basis of regional linkage

    Research Project

    Research Category

    Grant-in-Aid for University and Society Collaboration

    Research Field Thoracic surgery
    Research Institution The University of Tokyo
    Principal Investigator

    TAKAMOTO Shinichi Cardiac Surgery, Professor

    Project Period (FY) 2000 – 2002Completed
    Keywords Allograft tissue / Cryopreservation / Tissue transplantation / Tissue bank / Network
    Research Abstract 1. Founding the Network for allograft tissue procurement
    Research Products of this project Publications (61 results)
  • 20. 吸収性素材を用いた心膜再建に関する実験的研究

    Research Project

    Research Category

    Grant-in-Aid for Exploratory Research

    Research Field Thoracic surgery
    Research Institution Tohoku University
    Principal Investigator

    田林 晄一 東北大学, 大学院・医学系研究科, 教授

    Project Period (FY) 1999 – 2000Completed
    Keywords 代用心膜 / ゼラチン / ゴアテックス / カプロラクトン / 吸収性素材 / 心臓癒着 / 心膜 / 乳酸-カプロラクトン共重合体 / ポリテトラフルオロエチレン
    Research Abstract 目的:本研究の目的は心膜の代用物として吸収性素材である架橋ゼラチンシート、乳酸-カプロラクトン共重合体シートを用い,術後遠隔期の癒着の程度をexpanded-polytetra-fluoroethylene(e-PTFE)シート,自己心膜で閉鎖した群と比較することにある。平成11年、12年度中に以下 ...
    Research Products of this project Publications (3 results)
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