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Functions of RecQ family helicases in DNA replication, repair, and damage avoidance

Research Project

Project/Area Number 17013005
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionTohoku University

Principal Investigator

ENOMOTO Takemi  Tohoku University, 大学院・薬学研究科, 教授 (80107383)

Project Period (FY) 2005 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥71,500,000 (Direct Cost: ¥71,500,000)
Fiscal Year 2009: ¥14,300,000 (Direct Cost: ¥14,300,000)
Fiscal Year 2008: ¥14,300,000 (Direct Cost: ¥14,300,000)
Fiscal Year 2007: ¥14,300,000 (Direct Cost: ¥14,300,000)
Fiscal Year 2006: ¥14,300,000 (Direct Cost: ¥14,300,000)
Fiscal Year 2005: ¥14,300,000 (Direct Cost: ¥14,300,000)
Keywords癌 / ブルーム症候群 / ロスモンド・トムソン症候群 / RecQファミリーへリカーゼ / DNA複製 / DNA組換え / 姉妹染色分体接着 / RecQファミリーヘレカーゼ / DNA傷害回避 / BLM / RECQL4 / KNA組換え / ブルーム症侯群 / RecQフミリーヘリカーゼ / RECL4 / RecQヘリカーゼ / Sgs1 / DNA複製フォーク / 傷害回避 / ワーナー症候群 / Sgsl / 障害回避
Research Abstract

Human cells possess five RecQ family helicases, RECQL1, BLM, WRN, RTS, and RECQL5, whose defects cause a predisposition to cancer. In this study, functions of these RecQ family helicases were investigated and following results were obtained. BLM functions at the last stage of DNA replication, segregation of replicated DNA and sister chromatid cohesion. RTS is involved in DNA replication and repair of DNA double strand breaks. Finally, RECQL1 and RECQL5 are involved in early stages of recombination.

Report

(6 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • Research Products

    (121 results)

All 2010 2009 2008 2007 2006 2005

All Journal Article (87 results) (of which Peer Reviewed: 68 results) Presentation (29 results) Book (5 results)

  • [Journal Article] RecQL5 promotes genome stabilization trough two parallel mechanisms-Interacting with RNA polymerase II and acting as a helicase2010

    • Author(s)
      Islam, M.N., Fox. D. III, Guo, R., Enomoto, T., Wang, W
    • Journal Title

      Mol. Cell. Biol 30

      Pages: 2460-2472

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Deregulated Cdc6 inhibits DNA replication and suppresses Cdc7-dependent phosphorylation of Mcm2-7 complex in Xenopus egg extracts2010

    • Author(s)
      Kundu, L.R.
    • Journal Title

      Nuc.Acids Res. (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] RecQL5 promotes genome stabilization through two parallel mechanism Interacting with RNA polymerase II and acting as a helicase2010

    • Author(s)
      Islam, M. N.
    • Journal Title

      Mol.Cell.Biol. (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Global analysis of mutual interaction surfaces of nucleosomes with comprehensive point mutants2009

    • Author(s)
      Sakamoto, M., Noguchi, S., Kawashima, S., Okada, Y., Enomoto, T., Seki, M., Horikoshi, M
    • Journal Title

      Genes Cells 14

      Pages: 1271-1330

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Structure of the Cdt1 C-terminal domain: conservation of the winged helix fold in replication licensing factors2009

    • Author(s)
      Khayrutdinov, B.I., Bae, W.J., Yun, Y.M., Lee, J.H., Tsuyama, T., Kim. J.J., Hwang, E., Ryu, K.S., Cheong, H.K., Cheong, C., Ko, J.S., Enomoto, T., Karplus, P.A., Guntert. P., Tada, S., Jeon, Y.H., Cho, Y
    • Journal Title

      Protein Sci 18

      Pages: 2252-2264

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of heliquinomycin on the activity of human MCM4/6/7 helicase2009

    • Author(s)
      Ishimi, Y., Sugiyama, T., Nakaya, R., Kanamori, M., Kohno, T., Enomoto, T., Chino, M
    • Journal Title

      FEBS J 276

      Pages: 3382-3391

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Accumulation of sumoylated Rad52 in checkpoint mutants perturbed in DNA replication2009

    • Author(s)
      Ohuchi, T., Seki, M., Kugou, K., Tada, S., Ohta, K., Enomoto, T
    • Journal Title

      DNA Repair 8

      Pages: 690-696

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Alternative title: Generation and characterization of cells that can be conditionally depleted of mitochondrial SOD22009

    • Author(s)
      Takada, S., Inoue, E., Tano, K., Yoshii, H., Abe, T., Yoshimura, A., Akita, M., Tada, S., Watanabe, M., Seki, M., Enomoto, T
    • Journal Title

      Biochem. Biophys. Res. Commun 379

      Pages: 233-238

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Repression of nascent strand elongation by deregulated Cdt1 during DNA replication in Xenopus egg extracts2009

    • Author(s)
      Tsuyama, T., Watanabe, S., Aoki, A., Cho, Y., Seki, M., Enomoto, T., Tada, S
    • Journal Title

      Mol. Bio. Cell 20

      Pages: 937-947

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Global analysis of mutual interaction surfaces of nucleosomes with comprehensive point mutants2009

    • Author(s)
      Sakamoto, M.
    • Journal Title

      Genes Cells 14

      Pages: 1271-1330

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structure of the Cdt1 C-terminal domain : conservation of the winged helix fold in replication licensing factors2009

    • Author(s)
      Khayrutdinov, B.
    • Journal Title

      Protein Sci. 18

      Pages: 2252-2264

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of heliquinomycin on the activity of human MCM4/6/7 helicase2009

    • Author(s)
      Ishimi, Y.
    • Journal Title

      FEBS Journal 276

      Pages: 3382-3391

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Physical and functional interaction between WRNIPI and RAD182009

    • Author(s)
      Yoshimura, A.
    • Journal Title

      Genes Genet.System 84

      Pages: 171-178

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Accumulation of sumoylated Rad52 in checkpoint mutants perturbed in DNA replication2009

    • Author(s)
      Ohuchi, T.
    • Journal Title

      DNA Repair 8

      Pages: 690-696

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Generation and characterization of cells that can be conditionally depleted of mitochondrial SOD22009

    • Author(s)
      Takada, S.
    • Journal Title

      Biochem.Biophys.Res.Commun. 379

      Pages: 233-238

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Repression of nascent strand elongation by deregulated Cdt1 during DNA replication in Xenopus egg extracts2009

    • Author(s)
      Tsuyama, T.
    • Journal Title

      Mol.Biol.Cell 20

      Pages: 937-947

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Repression of nascent strand elongation by deregulated Cdtl during DNA replication in Xenonus egg extracts2009

    • Author(s)
      Tsuyama, T
    • Journal Title

      Mol. Biol. Cell 20

      Pages: 937-947

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Generation and characterization of cells that can be conditionally depleted of mitochondrial SOD22009

    • Author(s)
      Takada, S
    • Journal Title

      Biochem. Biophys. Res. Commun 379

      Pages: 233-238

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Accumnlatin of sumoylated Rad52 in checkpoint mutants perturbed in DNA replication2009

    • Author(s)
      Ohuchi, T
    • Journal Title

      DNA Repair (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel function for Rad17 in homologous recombination2008

    • Author(s)
      Nishino, K., Inoue, E., Takada, S., Abe, T., Akita, M., Yoshimura, A., Tada, S., Kobayashi, M., Yamamoto, K., Enomoto, T
    • Journal Title

      Genes Genet. Syst 83

      Pages: 427-431

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] RMI, a new OB-fold complex essential for Bloom syndrome protein to maintain genome stability2008

    • Author(s)
      Xu, D., Guo, R., Sobeck, A., Bachrati, C.Z., Yang, J., Enomoto, T., Brown, G.W., Hoatlin, M.E., Hickson, I.D., Wang W
    • Journal Title

      Gene Dev 22

      Pages: 2843-2855

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] KU70/80, DNA-PKcs, and Artemis are essential for the rapid induction of apoptosis after massive DSB formation2008

    • Author(s)
      Abe, T., Ishiai, M., Hosono, Y., Yoshimura, A., Tsuji, H., Tada, S., Adachi, N., Koyama, H., Takata, M., Takeda, S., Enomoto, T., Seki, M
    • Journal Title

      Cell Signal 20

      Pages: 1978-1985

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Nuclear localization of Rad52 is pre-requisite for its sumoylation2008

    • Author(s)
      Ohuchi, T., Seki, M., Enomoto, T
    • Journal Title

      Biochem. Biophys. Res. Commun 372

      Pages: 126-130

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Rad52 sumoylation and its involvement in the efficient induction of homologous recombination2008

    • Author(s)
      Ohuchi, T., Seki, M., Branzei, D., Maeda, D., Ui, A., Ogiwara, H., Tada, S., Enomoto, T
    • Journal Title

      DNA Repair 7

      Pages: 879-889

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Analyses of functional interaction between RECQL1, RECQL5, and BLM which physically interact with DNA topoisomerase III・2008

    • Author(s)
      Otsuki, M., Seki, M., Inoue, E., Abe. T., Narita, Y., Yoshimura, A., Tada, S., Ishii, Y., Enomoto, T
    • Journal Title

      Biochim. Biophys. Acta 1782

      Pages: 75-8

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Analyses of functional interaction between RECQL1。 RECQL5, and BLM which physically interact with DNA tonoisomerase IIIα2008

    • Author(s)
      Otsuld, M
    • Journal Title

      Biochim. Biophys. Acta 1782

      Pages: 75-81

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rad52 sumoylation and its involvement in the efficient induction of homologous recombination2008

    • Author(s)
      Ohuchi, T
    • Journal Title

      DNA Repair 7

      Pages: 879-889

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nuclear localization of Rad52 is pre-requisite for its sumoylation2008

    • Author(s)
      Ohuchi, T
    • Journal Title

      Biochem. Biophys. Res. Commun 372

      Pages: 126-130

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] RMI, a new OB-fold complex essential for Bloom syndrome protein to maintain genome stability2008

    • Author(s)
      Xu, D
    • Journal Title

      Genes Dev 22

      Pages: 2843-2855

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel function for Rad17 in homologous recombination2008

    • Author(s)
      Nishino, K
    • Journal Title

      Genes Genet. System 83

      Pages: 427-431

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rad52 sumoylation and its involvement in the efficient induction of homologous recombination2008

    • Author(s)
      Takashi Ohuchi
    • Journal Title

      DNA Repair (In press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Vertebrate WRNIP1 and BLM are required for efficient maintenance of genome stability2008

    • Author(s)
      Tomoko Hayashi
    • Journal Title

      Genes Genet. Syst. 83

      Pages: 95-100

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Analyses of functional interaction between RECQL1, RECQL5, and BLM which physically interact with DNA topoisomerase IIIα2008

    • Author(s)
      Makoto Otsuki
    • Journal Title

      Biochim. Biophys. Acta 1782

      Pages: 75-81

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Functional interactions between BLM and XRCC3 in the cell2007

    • Author(s)
      Otsuki, M., Seki, M., Inoue, E., Yoshimura, A., Kato, G., Yamanouchi, S., Kawabe, Y., Tada, S., Shinohara, A., Komura, J., Ono, T., Takeda, S., Ishii, Y., Enomoto, T
    • Journal Title

      J. Cell Biol 179

      Pages: 53-63

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Ctf18 is required for homologous recombination -mediated double strand break repair2007

    • Author(s)
      Ogiwara, H., Ohuchi, T., Ui, A., Tada, S., Enomoto, T., Seki, M
    • Journal Title

      Nuc. Acids Res 35

      Pages: 4989-5000

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Rmi1, a member of the Sgs1-Top3 complex in budding yeast, contributes to sister chromatid cohesion2007

    • Author(s)
      Lai M.S., Seki, M., Ui, A., Enomoto, T
    • Journal Title

      EMBO Reports 8

      Pages: 685-690

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Activation of a novel pathway involving Mms1 and Rad59 in sgs1 cells2007

    • Author(s)
      Ui, A., Seki, M., Ogiwara, H., Lai, M.S., Yamamoto, K., Tada, S., Enomoto, T
    • Journal Title

      Biochem. Biophys. Res. Commun 356

      Pages: 1031-1037

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] INO80 chromatin remodeling complex functions in sister chromatid cohesion2007

    • Author(s)
      Ogiwara, H., Enomoto, T., Seki, M
    • Journal Title

      Cell Cycle 6

      Pages: 1090-1095

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Actin-related protein Arp4 functions in kinetochore construction2007

    • Author(s)
      Ogiwara, H., Ui, A., Kawashima, S., Kugou, K., Onoda, F., Iwahashi, H., Harata, M., Ohta, K., Enomoto, T., Seki, M
    • Journal Title

      Nuc. Acids Res 35

      Pages: 3109-3117

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] INO80 complex is required for damage-induced recombination2007

    • Author(s)
      Kawashima, S., Ogiwara, H., Tada, S., Harata, M., Wintersberger, U., Enomoto, T., Seki, M
    • Journal Title

      Biochem. Biophys. Res. Commun 355

      Pages: 835-841

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Ames test-negative carcinogen, ortho-phenyl phenol, binds tubulin and causes aneuploidy in budding yeast2007

    • Author(s)
      Nunoshiba, T., Watanabe, E., Takahashi, T., Daigaku., Y., Ishikawa, S., Mochizuki, M., Ui, A., Enomoto, T., Yamamoto, K
    • Journal Title

      Mut. Res 617

      Pages: 90-97

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Rad50 is involved in MMS-induced recombination between homologous chromosomes in mitotic cells2007

    • Author(s)
      Tomizawa, Y., Ui, A., Onoda, F., Ogiwara, H., Tada, S., Enomoto, T., Seki, M
    • Journal Title

      Genes Genet. Syst 82

      Pages: 157-160

    • NAID

      10024394124

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Possible involvement of RecQL4 in the repair of double-strand DNA breaks in Xenopus egg extracts2007

    • Author(s)
      Kumata, Y., Tada, S., Yamanada, Y., Tsuyama, T., Kobayashi, T., Dong, Y. -P., Ikegami, K., Murofushi, H., Seki, M., Enomoto, T
    • Journal Title

      Biochim. Biophys. Acta 1773

      Pages: 556-564

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Chl1 and Ctf4 are required for damage-induced recombinations. Biochem2007

    • Author(s)
      Ogiwara, H., Ui, A., Lai M.S., Enomoto, T., Seki M
    • Journal Title

      Biophys. Res. Commun 354

      Pages: 222-226

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Role of Elg1 protein in the double-strand breaks repair2007

    • Author(s)
      Ogiwara, H., Ui, A., Enomoto, T., Seki, M
    • Journal Title

      Nuc. Acids Res 35

      Pages: 353-362

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Functional interactions between BLM and XRCC3 in the cell2007

    • Author(s)
      Makoto Otsuki
    • Journal Title

      J. Cell Biol. 179

      Pages: 53-63

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ctfl8 is required for homologous recombination-mediated. double-strand break repair2007

    • Author(s)
      Hideaki Ogiwara
    • Journal Title

      Nucleic Acids Res. 35

      Pages: 4989-5000

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rmil, a member of the Sgsl-Top3 complex in budding yeast, contributes to sister chromatidcohesion2007

    • Author(s)
      Mong Sing Lai
    • Journal Title

      EMBO Rep. 8

      Pages: 685-690

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Activation of a novel pathway involving Mmsl and Rad59 in sgs1 cells2007

    • Author(s)
      Ayako Ui
    • Journal Title

      Biochem. Biophys. Res. Commun. 356

      Pages: 1031-1037

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The INO80 complex is required for damage-induced recombination2007

    • Author(s)
      Satoshi Kawashima
    • Journal Title

      Biochem. Biophys. Res. Commun. 355

      Pages: 835-841

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Possible involvement of RecQL4 in the repair of double-strand DNA breaks in Xenopus egg extracts2007

    • Author(s)
      Yuji Kumata
    • Journal Title

      Biochim. Biophys. Acta 1773

      Pages: 556-564

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The INO80 chromatin remodeling complex functions in sister chromatid cohesion2007

    • Author(s)
      Hideaki Ogiwara
    • Journal Title

      Cell Cycle 6

      Pages: 1090-1095

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Actin-related protein Arp4 functions in kinetochore assembly2007

    • Author(s)
      Hideaki Ogiwara
    • Journal Title

      Nucleic Acids Res. 35

      Pages: 3109-3117

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rad50 is involved in MMS-induced recombination between homologous chromosomes in mitotic cells.2007

    • Author(s)
      Yuji Tomizawa
    • Journal Title

      Genes Genet. Syst. 82

      Pages: 157-160

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chll and Ctf4 are required for damage-induced recombinations2007

    • Author(s)
      Hideaki Ogiwara
    • Journal Title

      Biochem. Biophys. Res. Commun. 354

      Pages: 222-226

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of Elg1 protein in the double-strand breaks repair2007

    • Author(s)
      Hideaki Ogiwara
    • Journal Title

      Nucleic Acids Res. 35

      Pages: 353-362

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of Elg1 protein in the double-strand breaks repair.2007

    • Author(s)
      Hideaki Ogiwara
    • Journal Title

      Nucleic Acids Res. 35・2

      Pages: 353-362

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Chll and Ctf4 are required for damage-induced recombinations.2007

    • Author(s)
      Hideaki Ogiwara
    • Journal Title

      Biochem. Biophys. Res. Commun. 354・1

      Pages: 222-226

    • Related Report
      2006 Annual Research Report
  • [Journal Article] RecQL4 functions in Ku and DNA-dependent protein kinase-mediated double-strand break repair in Xenopus egg extracts.2007

    • Author(s)
      Yuji Kumata
    • Journal Title

      Biochim. Biophys. Acta 1773・4

      Pages: 556-564

    • Related Report
      2006 Annual Research Report
  • [Journal Article] INO80 complex is required for damage-induced recombination.2007

    • Author(s)
      Satoshi Kawashima
    • Journal Title

      Biochem. Biophys. Res. Commun. 355・3

      Pages: 835-841

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Actin-related protein Arp4 functions in kinetochore construction.2007

    • Author(s)
      Hideaki Ogiwara
    • Journal Title

      Nucleic Acids Res. (in press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] INO80 chromatin remodeling complex functions in sister chromatid cohesion.2007

    • Author(s)
      Hideaki Ogaiwara
    • Journal Title

      Cell Cycle (in press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Chromatin loading of Smc5/6 is induced by DNA replication but not by DNA double-strand breaks2006

    • Author(s)
      Tsuyama, T., Inou, K., Seki, M., Seki, T., Kumata, Y., Kobayashi, T., Kimura, K., Hanaoka, F., Enomoto, T., Tada, S
    • Journal Title

      Biochem. Biophys. Res. Commun 351

      Pages: 935-939

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mgs1 and Rad18/Rad5/Mms2 are required for survival of novel temperature/cold sensitive mutant alleles of Pol31, the second subunit of DNA polymerase・, in Saccharomyces cerevisiae2006

    • Author(s)
      Davoodi Vijeh Motlagh, N., Branzei, D., Seki, M., Enomoto, T
    • Journal Title

      DNA Repair 5

      Pages: 1459-1474

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] A novel Rad18 function involved in the protection of the vertebrate genome after exposure to camptothecin2006

    • Author(s)
      Yoshimura, A., Nishino, K., Takezawa, J., Tada, S., Kobayashi, T., Sonoda, E., Kawamoto, T., Takeda, S., Ishii, Y., Yamada, K., Enomoto, T., Seki, M
    • Journal Title

      DNA Repair 5

      Pages: 1307-1316

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Ubc9 and Mms21 mediated sumoylation counteracts recombinogenic events at damaged replication forks2006

    • Author(s)
      Branzei, D., Sollier, J., Liberi, G., Zhao, X, Maeda, D., Seki, M., Enomoto, T., Ohta, K., Foiani, M
    • Journal Title

      Cell 127

      Pages: 509-522

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] BLM is an early responder to DNA double-strand breaks. Biochem. Biophys2006

    • Author(s)
      Karmakar, P., Seki, M., Kanamori, M., Hashiguchi, K., Ohtsuki, M., Murata, E., Inoue, E., Tada, S., Lan, L., Yasui, A., Enomoto, T
    • Journal Title

      Res. Commun 348

      Pages: 62-69

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Loss of heterozygosity in yeast can occur by ultraviolet irradiation during the S phase of the cell cycle2006

    • Author(s)
      Daigaku, Y., Mashiko, S., Mishiba, K., Yamamura, S., Ui, A., Enomoto, T., Yamamoto, K
    • Journal Title

      Mutat. Res 600

      Pages: 177-183

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Bloom helicase and DNA topoisomerase III・are involved in the dissolution of sister chromatids2006

    • Author(s)
      Seki, M., Nakagawa, T., Seki, T., Kato, G., Tada, T., Takahashi, Y., Yoshimura, A., Kobayashi, T., Aoki, A., Otsuki, M., Habermann, F.A., Tanabe, H., Ishii, Y., Enomoto, T
    • Journal Title

      Mol. Cell. Biol 26

      Pages: 6299-6307

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dpb11, the budding yeast homologue of TopBP1, functions with the checkpoint clamp in recombination repair2006

    • Author(s)
      Ogiwara, H., Ui, A., Onoda, F., Tada, S., Enomoto, T., Seki, M
    • Journal Title

      Nuc. Acids Res 34

      Pages: 3389-3398

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Ubc9 and Mms21 mediated sumoylation counteracts recombinogenic events at demaged replication forks.2006

    • Author(s)
      Dana Branzei
    • Journal Title

      Cell 127・3

      Pages: 509-522

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Bloom helicase and DNA topoisomerase IIIα are involved in the dissolution of sister chromatids.2006

    • Author(s)
      Masayuki Seki
    • Journal Title

      Mol. Cell. Biol. 26・16

      Pages: 6299-6307

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Analyses of the interaction of WRNIP1 with Werner syndrome protein (WRN) in vitro and in the cell.2006

    • Author(s)
      Yoh-ichi Kawabe
    • Journal Title

      DNA Repair 5・7

      Pages: 816-828

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Dpb11, the budding yeast homologue of TopBP1, functions with the checkpoint clamp in recombination repair.2006

    • Author(s)
      Hideaki Ogiwara
    • Journal Title

      Nucleic Acids Res. 34・11

      Pages: 3389-3398

    • Related Report
      2006 Annual Research Report
  • [Journal Article] BLM is an early responder to DNA double-strand breaks.2006

    • Author(s)
      Parimal Karmakar
    • Journal Title

      Biochem. Biophys. Res. Commun. 348・1

      Pages: 62-69

    • Related Report
      2006 Annual Research Report
  • [Journal Article] A novel Rad18 function involved in the protection of the vertebrate genome after exposure to camptothecin.2006

    • Author(s)
      Akari Yoshimura
    • Journal Title

      DNA Repair 5・11

      Pages: 1307-1316

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Mgsl and Rad18/Rad5/Mms2 are require for survival of novel temperature/cold sensitive mutant alleles of Pol31, the second subunit of DNA polymerase d, in Sacharomyces cerevisiae.2006

    • Author(s)
      N.Davoodi Vijeh Motlagh
    • Journal Title

      DNA Repair 5・12

      Pages: 1459-1474

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Chromatin loading of Smc5/6 is induced by DNA replication but not by DNA double-strand breaks.2006

    • Author(s)
      Takashi Tsuyama
    • Journal Title

      Biochem. Biophys. Res. Commun. 351・4

      Pages: 935-939

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Caenorhabditis elegans geminin homologue participates in cell cycle regulation and germ line development2005

    • Author(s)
      Yanagi, K., Mizuno, T., Tsuyama, T., Tada, S., Iida, Y., Sugimoto, A., Eki, T., Enomoto, T., Hanaoka F
    • Journal Title

      J. Biol. Chem 280

      Pages: 19689-19694

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Functional relationships of FANCC to homologous recombination, translesion synthesis, and BLM2005

    • Author(s)
      Hirano, S., Yamamoto, K., Ishiai, M., Yamazoe, M., Seki, M., Matsushita, N., Ohzeki, M., Yamashita, Y.M., Arakawa, H., Buerstedde, J. -M., Enomoto, T., Takeda, S., Thompson, L.H., Takata, M
    • Journal Title

      EMBO J 24

      Pages: 418-427

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Human Werner helicase interacting protein 1 (WRNIP1) functions as a novel modulator for DNA polymerase・・2005

    • Author(s)
      Tsurimoto, T., Shinozaki, A., Yano, M., Seki, M., Enomoto, T
    • Journal Title

      Genes Cells 10

      Pages: 13-22

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] DNA topoisomerase III is essential for damage-induced recombination2005

    • Author(s)
      Ui, A., Seki, M., Ogiwara, H., Onodera, R., Fukushige, S., Onoda, F., Enomoto, T
    • Journal Title

      DNA Repair 4

      Pages: 191-201

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] The ability of Sgs1 to interact with DNA topoisomerase III is essential for damage-induced recombination.2005

    • Author(s)
      Ayako Ui
    • Journal Title

      DNA Repair 4

      Pages: 191-201

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Epistasis between Fanconi anemia protein FANCC and BLM helicase in suppressing sister chromatid exchanges.2005

    • Author(s)
      Seiki Hirano
    • Journal Title

      EMBO Journal 24

      Pages: 418-427

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Licensing for DNA replication requires a strict sequential assembly of Cdc6 and Cdt1 onto chromatin in Xenopus egg extracts.2005

    • Author(s)
      Takashi Tsuyama
    • Journal Title

      Nucleic Acids Research 33

      Pages: 765-775

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Caenorhabditis elegans eminin homologue participates in cell cycle regulation and germ line development.2005

    • Author(s)
      Ken-ichiro Yanagi
    • Journal Title

      J.Biol.Chem. 280

      Pages: 19689-19694

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Human Werner helicase interacting protein 1 (WRNIP1) functions as a novel modulator for DNA polymerase δ.2005

    • Author(s)
      Toshiki Tsurimoto
    • Journal Title

      Genes to Cells 10

      Pages: 12-22

    • Related Report
      2005 Annual Research Report
  • [Presentation] Acetylation of histone H3-K56 regulates homologous recombination2009

    • Author(s)
      遠藤博人
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2009-12-11
    • Related Report
      2009 Annual Research Report
  • [Presentation] A mutant protein of histone chaperone CIA/Asf1 defective in disrupting histone(H3-H4)_2 tetramer accelerates rate of DNA replication2009

    • Author(s)
      大隅達也
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2009-12-11
    • Related Report
      2009 Annual Research Report
  • [Presentation] Analysis of DNA replication repression by excess Cdt12009

    • Author(s)
      牛田磨理
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2009-12-10
    • Related Report
      2009 Annual Research Report
  • [Presentation] Nuclear superoxide may trigger spontaneous sister chromatid exchanges2009

    • Author(s)
      井上絵里
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2009-12-09
    • Related Report
      2009 Annual Research Report
  • [Presentation] 親鎖ヌクレオソーム中のヒストン成分の娘鎖への分配機構解明に向けて2009

    • Author(s)
      石川勝幸
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      ポートアイランド(神戸)
    • Year and Date
      2009-10-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] DNA複製チェックポイント因子 Claspin とRad17の機能的関連の解析2009

    • Author(s)
      細野嘉史
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      ポートアイランド(神戸)
    • Year and Date
      2009-10-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] DNA複製に必須なCdc45の新規機能の解析2009

    • Author(s)
      大隅達也
    • Organizer
      第48回日本薬学会東北支部大会
    • Place of Presentation
      東北薬科大学(仙台)
    • Year and Date
      2009-10-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] ヒストンシャペロンFACTのDNA複製における機能解析2009

    • Author(s)
      阿部拓也
    • Organizer
      第6回 東北大学バイオサイエンスシンポジウム
    • Place of Presentation
      仙台国際センター(仙台)
    • Year and Date
      2009-06-16
    • Related Report
      2009 Annual Research Report
  • [Presentation] 染色体分配におけるヒストンの機能的役割とクロマチン制御機構の解析2009

    • Author(s)
      川嶋聡
    • Organizer
      第6回 東北大学バイオサイエンスシンポジウム
    • Place of Presentation
      仙台国際センター(仙台)
    • Year and Date
      2009-06-16
    • Related Report
      2009 Annual Research Report
  • [Presentation] Regulation of DNA replication initiation by Cdc6 and its implication in anti-cancer drug desining2009

    • Author(s)
      Kundu, L.R.
    • Organizer
      第6回 東北大学バイオサイエンスシンポジウム
    • Place of Presentation
      仙台国際センター(仙台)
    • Year and Date
      2009-06-16
    • Related Report
      2009 Annual Research Report
  • [Presentation] The role of FACT in DNA replication2009

    • Author(s)
      Takemi Enomoto
    • Organizer
      Swiss-Japan joint metting on the molecular mechanisms regulating "Chromosome dynamics and Genome stability"
    • Place of Presentation
      Villars Ollons, Switzerland
    • Year and Date
      2009-05-15
    • Related Report
      2009 Final Research Report
  • [Presentation] The role of FACT in DNA replication2009

    • Author(s)
      Enomoto, T.
    • Organizer
      Swiss-Japan joint meeting on the molecular mechanisms regulating "Chromosome dynamics and genome stability"
    • Place of Presentation
      Villars Ollons(スイス)
    • Year and Date
      2009-05-15
    • Related Report
      2009 Annual Research Report
  • [Presentation] DNA傷害に応じたRecQL4の動態と相互作用タンパク質の機能解明2008

    • Author(s)
      池上京子
    • Organizer
      第31回日本分子生物学会年会第81回日本生化学会大会合同大会
    • Place of Presentation
      兵庫県神戸市
    • Year and Date
      2008-12-12
    • Related Report
      2008 Annual Research Report
  • [Presentation] 高等動物細胞におけるチェックポイント因子Claspinの機能の解析2008

    • Author(s)
      秋田玄武
    • Organizer
      第31回日本分子生物学会年会第81回日本生化学会大会合同大会
    • Place of Presentation
      兵庫県神戸市
    • Year and Date
      2008-12-12
    • Related Report
      2008 Annual Research Report
  • [Presentation] ブルーム症候群原因遺伝子産物BLMのDNA複製及び姉妹染色分体接着における役割(Functions of the Bloom syndrome responsible gene product in DNA replication and sister chromatid cohesion)2008

    • Author(s)
      榎本武美
    • Organizer
      日本環境変異原学会第37回大会
    • Place of Presentation
      沖縄
    • Year and Date
      2008-12-05
    • Related Report
      2009 Final Research Report
  • [Presentation] ブルーム症候群原因遺伝子産物BLMのDNA複製及び姉妹染色分体接着における役割2008

    • Author(s)
      榎本武美
    • Organizer
      日本環境変異原学会第37回大会
    • Place of Presentation
      沖縄県宜野湾
    • Year and Date
      2008-12-05
    • Related Report
      2008 Annual Research Report
  • [Presentation] Effects of deregulating Cdc6 during the initiation of DNA replication2008

    • Author(s)
      Kundu, R. L
    • Organizer
      The 6th 3R Symposium
    • Place of Presentation
      静岡県嬬恋市
    • Year and Date
      2008-10-27
    • Related Report
      2008 Annual Research Report
  • [Presentation] Functional analysis of RecQL4 using RecQL4 mutated cells2008

    • Author(s)
      Abe, T
    • Organizer
      The 6th 3R Symposium
    • Place of Presentation
      静岡県嬬恋市
    • Year and Date
      2008-10-27
    • Related Report
      2008 Annual Research Report
  • [Presentation] Rmi1, a member of the Sgs1-Top3 complex in budding yeast, contributes to sister chromatid cohesion2008

    • Author(s)
      Mong Sing Lai, Masayuki Seki, Ayako Ui, Takemi Enomoto
    • Organizer
      2008 EMBO conference on DNA recombination
    • Place of Presentation
      Cioccol, Italy
    • Year and Date
      2008-05-21
    • Related Report
      2009 Final Research Report
  • [Presentation] Rmil, a member of the Sgsl-Top3 complex in budding yeast, contributes to sister chromatid cohesion2008

    • Author(s)
      Lai, M. S
    • Organizer
      2008 EMBO conference on DNA recombination
    • Place of Presentation
      I1 Cioccol, Italy
    • Year and Date
      2008-05-21
    • Related Report
      2008 Annual Research Report
  • [Presentation] RecQL4のDNA二本鎖切断誘発時における挙動の解析2008

    • Author(s)
      池上京子、多田周右、Li Lan、安井明、関政幸、榎本武美
    • Organizer
      日本薬学会第128年会
    • Place of Presentation
      横浜
    • Year and Date
      2008-03-27
    • Related Report
      2009 Final Research Report
  • [Presentation] Illegitimate activation of Cdt1 at S-phase possibly leads to a halt of nascent strand elongation in DNA re-replication2007

    • Author(s)
      Shusuke Tada, Masayuki Seki, Takemi Enomoto
    • Organizer
      第66回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2007-10-03
    • Related Report
      2009 Final Research Report
  • [Presentation] Novel functions of Sgsl (BLM), Top3 (TopoIII alpha), and Rmi1 (BLAP75) during DNA replication2007

    • Author(s)
      Mong Sing Lai
    • Organizer
      第3回日米DNA修復会議
    • Place of Presentation
      仙台市
    • Year and Date
      2007-05-07
    • Related Report
      2007 Annual Research Report
  • [Presentation] BLM functions together with XRCC3 for resumption of stalled replication forks2006

    • Author(s)
      Makoto Otsuki, Masayuki Seki, Eri Inoue, Genta Katoh, Akari Yoshimura, Shusuke Tada, Yutaka Ishii, Shunichi Takeda, Takemi Enomoto
    • Organizer
      20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB congress
    • Place of Presentation
      Kyoto
    • Year and Date
      2006-06-18
    • Related Report
      2009 Final Research Report
  • [Presentation] Rmi1/Nce4, a subunit of the Sgs1-Top3 complex of Saccharomyces cerevisiae is involved in homologous recombination and establishment of sister chromatid cohesion2006

    • Author(s)
      Mong Sing Lai、宇井彩子、関政幸、榎本武美
    • Organizer
      日本薬学会第126年会
    • Place of Presentation
      仙台
    • Year and Date
      2006-03-29
    • Related Report
      2009 Final Research Report
  • [Presentation] DNA二本鎖切断修復におけるRecQL4の機能の解析2006

    • Author(s)
      山名田弓枝、多田周右、二藤望、熊田裕司、小林貴之、関政幸、榎本武美
    • Organizer
      日本薬学会第126年会
    • Place of Presentation
      仙台
    • Year and Date
      2006-03-28
    • Related Report
      2009 Final Research Report
  • [Presentation] BLM is an early responder to DNA double strand breaks2005

    • Author(s)
      Parimal Karmakar, Masayuki Seki, Makoto Kanamori, Shusuke Tada, Li Lan, Kazunari Hashiguchi, Akira Yasui, Takemi Enomoto
    • Organizer
      The 5th Symposium on DNA Replication, Recombination and Repair
    • Place of Presentation
      Hyogo
    • Year and Date
      2005-11-13
    • Related Report
      2009 Final Research Report
  • [Presentation] BLM acts together with XRCC3 upon damage induction2005

    • Author(s)
      Makoto Otsuki, Masayuki Seki, Genta Kato, Eri Inoue, Akari Yoshimura, Shusuke Tada, Takemi Enomoto
    • Organizer
      第78回日本生化学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2005-10-22
    • Related Report
      2009 Final Research Report
  • [Presentation] ブルーム症候群原因遺伝子産物の機能の解析2005

    • Author(s)
      関政幸、多田周右、榎本武美
    • Organizer
      第64回日本癌学会学術総会
    • Place of Presentation
      札幌
    • Year and Date
      2005-09-14
    • Related Report
      2009 Final Research Report
  • [Book] 蛋白質核酸酵素別冊;染色体サイクル2009

    • Author(s)
      関政幸・Mong Sing Lai・榎本武美
    • Publisher
      共立出版
    • Related Report
      2009 Final Research Report
  • [Book] 染色体サイクル2009

    • Author(s)
      関政幸
    • Publisher
      共立出版
    • Related Report
      2008 Annual Research Report
  • [Book] Reviews and protocols in DT40 research2006

    • Author(s)
      Seki, M., Tada, S., Enomoto, T
    • Publisher
      Springer
    • Related Report
      2009 Final Research Report
  • [Book] DT40 Handbook2006

    • Author(s)
      Masayuki Seki
    • Total Pages
      477
    • Publisher
      Springer
    • Related Report
      2006 Annual Research Report
  • [Book] DT40 Handbook2006

    • Author(s)
      Masayuki Seki
    • Publisher
      Springer(In press)
    • Related Report
      2005 Annual Research Report

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Published: 2005-04-01   Modified: 2018-03-28  

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